INT139840

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.55
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14)
nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)
MAPK14 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 6 98.96 Very High Very High Very High
cytokine 63 90.24 High High
Inflammation 116 87.32 High High
cINOD 1 66.28 Quite High
Inflammatory mediators 24 5.00 Very Low Very Low Very Low
chemokine 17 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
bradykinin 6 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cholesteatoma 48 89.20 High High
INFLAMMATION 150 87.32 High High
Adhesions 15 85.88 High High
Otitis Media 134 79.68 Quite High
Otitis Media With Effusion 92 74.80 Quite High
Disease 2 63.32 Quite High
Bacterial Infection 4 30.48 Quite Low
Hyperplasia 4 28.24 Quite Low
Metaplasia 4 27.76 Quite Low
Infection 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, Dex is able to increase the expression of MKP-1, which causes an inactivation of TNF-alpha-induced p38 MAPK and mediates inhibition of E-selectin expression.
Positive_regulation (causes) of Negative_regulation (inactivation) of p38 associated with dexamethasone
1) Confidence 0.21 Published 2007 Journal FASEB J. Section Abstract Doc Link 17099067 Disease Relevance 0.47 Pain Relevance 0.52
-Smad signaling, however, led to down-regulation of p38 by including MAPK phosphatase-1 (MKP-1), thereby acting as a negative regulator for MUC5AC induction (248).


Positive_regulation (led) of Negative_regulation (regulation) of p38
2) Confidence 0.03 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.09 Pain Relevance 0.15

General Comments

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