INT139845

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.95
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp4f18) endoplasmic reticulum (Cyp4f18)
Cyp4f18 (Mus musculus)
Pain Link Frequency Relevance Heat
methadone 8 99.04 Very High Very High Very High
carbamazepine 2 95.32 Very High Very High Very High
antiepileptic Drug 6 94.40 High High
withdrawal 2 88.00 High High
opiate 3 76.48 Quite High
Bioavailability 1 63.84 Quite High
depression 2 56.80 Quite High
sSRI 1 52.48 Quite High
fluoxetine 1 48.16 Quite Low
anesthesia 2 22.96 Low Low
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 2 88.00 High High
Fracture Healing 2 80.92 Quite High
Convulsion 12 76.24 Quite High
Osteoporosis 9 69.04 Quite High
Injury 2 68.56 Quite High
Dislocations 1 66.12 Quite High
Compression Fractures 1 61.36 Quite High
Hypocalcemia 1 58.88 Quite High
Respiratory Failure 2 57.76 Quite High
Hypercalcemia 1 57.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction or inhibition of CYP450 significantly modifies methadone pharmacodynamic properties.
Negative_regulation (inhibition) of CYP450 associated with methadone
1) Confidence 0.28 Published 2006 Journal Encephale Section Abstract Doc Link 17099560 Disease Relevance 0.23 Pain Relevance 0.61
Valproic acid is a CYP450 inhibitor.
Negative_regulation (inhibitor) of CYP450
2) Confidence 0.02 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2919461 Disease Relevance 0.72 Pain Relevance 0.18
This procedure is known to eliminate CYP450 activity while not affecting FMOs.
Negative_regulation (eliminate) of CYP450
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0 Pain Relevance 0
No inhibition of CYP450 was observed for any of these compounds in concentrations up to 1 microM.
Negative_regulation (inhibition) of CYP450
4) Confidence 0.00 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20304039 Disease Relevance 0 Pain Relevance 0

General Comments

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