INT139848

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1, Bace2) peptidase activity (Bace1, Bace2) Golgi apparatus (Bace1, Bace2)
endoplasmic reticulum (Bace1, Bace2) enzyme binding (Bace1)
Anatomy Link Frequency
cleavage 1
Bace1 (Mus musculus)
Bace2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 83.76 Quite High
Peripheral nervous system 5 75.00 Quite High
Thalamus 1 72.48 Quite High
Pain 1 61.92 Quite High
Inflammation 11 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Nav1.1 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 23 100.00 Very High Very High Very High
Syndrome 15 77.08 Quite High
Targeted Disruption 31 75.92 Quite High
Pain 1 61.92 Quite High
Disease 153 37.88 Quite Low
Cognitive Disorder 13 34.48 Quite Low
Stress 26 6.36 Low Low
Hypoxia 14 5.00 Very Low Very Low Very Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Apoptosis 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-secretase cleavage site [75, 76] and BACE2 appears to be primarily responsible for A?
secretase Binding (cleavage) of BACE2 in cleavage
1) Confidence 0.28 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.15 Pain Relevance 0.08
Bace1 is an endopeptidase that cleaves the amyloid precursor protein at the beta-secretase site.
Bace1 Binding (cleaves) of beta-secretase site associated with alzheimer's dementia
2) Confidence 0.10 Published 2006 Journal Nat. Neurosci. Section Abstract Doc Link 17099708 Disease Relevance 0.16 Pain Relevance 0.10

General Comments

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