INT139849

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.85
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (App, Bace1) endosome (Bace1) endoplasmic reticulum (Bace1)
enzyme binding (Bace1) extracellular matrix organization (App) DNA binding (App)
App (Mus musculus)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 27 75.00 Quite High
Nerve growth factor 3 66.00 Quite High
Pain 2 59.76 Quite High
antagonist 7 16.60 Low Low
agonist 10 12.16 Low Low
Inflammation 50 5.00 Very Low Very Low Very Low
ischemia 31 5.00 Very Low Very Low Very Low
Central nervous system 28 5.00 Very Low Very Low Very Low
cINOD 24 5.00 Very Low Very Low Very Low
cytokine 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 137 100.00 Very High Very High Very High
Apoptosis 66 88.68 High High
Adhesions 8 88.68 High High
Herpes Simplex Virus 1 81.84 Quite High
Pain 2 59.76 Quite High
Syndrome 86 57.28 Quite High
Disease 386 50.00 Quite Low
Cardiovascular Disease 11 32.84 Quite Low
Hypercholesterolemia 15 30.00 Quite Low
Targeted Disruption 173 8.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, another study failed to verify the interaction between APP and kinesin-I and the co-transport of BACE1 and PS1 with APP [28].
APP Binding (interaction) of BACE1
1) Confidence 0.41 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.30 Pain Relevance 0.03
Conversely, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
APP Binding (interaction) of BACE1
2) Confidence 0.36 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.09 Pain Relevance 0
Conversely, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
APP Binding (interaction) of BACE1
3) Confidence 0.36 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.09 Pain Relevance 0
Interestingly, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
APP Binding (interaction) of BACE1
4) Confidence 0.36 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.08 Pain Relevance 0
Interestingly, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
APP Binding (interaction) of BACE1
5) Confidence 0.36 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.08 Pain Relevance 0
Towards this end, Sauder et al. [142] used molecular modeling to simulate the BACE1 active site bound with wild-type or mutant APP substrates.
APP Binding (bound) of BACE1
6) Confidence 0.32 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.06 Pain Relevance 0
Bace1 is an endopeptidase that cleaves the amyloid precursor protein at the beta-secretase site.
amyloid precursor protein Binding (cleaves) of Bace1 associated with alzheimer's dementia
7) Confidence 0.12 Published 2006 Journal Nat. Neurosci. Section Abstract Doc Link 17099708 Disease Relevance 0.16 Pain Relevance 0.10

General Comments

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