INT139863

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 32
Disease Relevance 41.30
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eyes 1
RPE 1
fovea 1
amd (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 12 100.00 Very High Very High Very High
Inflammation 319 99.80 Very High Very High Very High
Nicotine 15 93.32 High High
Angina 27 85.00 Quite High
palliative 1 82.28 Quite High
cva 109 73.80 Quite High
depression 20 71.00 Quite High
ischemia 16 49.20 Quite Low
agonist 50 45.28 Quite Low
cytokine 18 41.88 Quite Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 2907 100.00 Very High Very High Very High
Hypertension 104 100.00 Very High Very High Very High
Diabetes Mellitus 104 100.00 Very High Very High Very High
INFLAMMATION 347 99.98 Very High Very High Very High
Geographic Atrophy 107 99.80 Very High Very High Very High
Apoptosis 95 99.12 Very High Very High Very High
Cataract 145 98.66 Very High Very High Very High
Disease 262 98.56 Very High Very High Very High
Nicotine Addiction 254 98.36 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 359 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cigarette smoke is the strongest environmental risk factor associated with AMD.
AMD Binding (associated) of associated with age-related macular degeneration
1) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.76 Pain Relevance 0
The mild severity of basal deposits falls short of changes associated with AMD.
AMD Binding (associated) of associated with age-related macular degeneration
2) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.60 Pain Relevance 0
While the genetic variations of several complement factors have been associated with AMD susceptibility, different studies also have identified a susceptibility locus for AMD may be located in or near the hypothetical LOC387715 gene [4], [5].
AMD Binding (associated) of associated with age-related macular degeneration
3) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.75 Pain Relevance 0.08
We used these established changes as endpoints for a study designed to determine if cigarette smoke induces evidence of changes associated with AMD.
AMD Binding (associated) of associated with age-related macular degeneration
4) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.30 Pain Relevance 0.04
Critical host factors that protect the RPE from oxidative injury may determine its susceptibility to tissue destruction or modify the intensity of inflammatory reaction associated with AMD.
AMD Binding (associated) of in RPE associated with inflammation, injury and age-related macular degeneration
5) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.55 Pain Relevance 0.05
Patients with intermediate AMD have extensive medium-sized, intermediate drusen, or one or more large drusen in one or both eyes.
AMD Binding (intermediate) of in eyes associated with ocular toxicity (including many sub-types) and age-related macular degeneration
6) Confidence 0.30 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 2.15 Pain Relevance 0
This neovascularization and leakage results in the changes in vision associated with neovascular AMD, including loss of VA, particularly when the fovea is involved.


AMD Binding (associated) of in fovea associated with age-related macular degeneration
7) Confidence 0.30 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.14 Pain Relevance 0
Using these definitions, lesions associated with neovascular AMD are often categorized clinically and angiographically as occult, classic, or mixed occult and classic (minimally or predominantly classic) CNV (AAO 2006).


AMD Binding (associated) of associated with age-related macular degeneration
8) Confidence 0.30 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.50 Pain Relevance 0
Similarly, exposure to ultraviolet (UV) light has been postulated as a cause of AMD, but no studies have demonstrated increased risk associated with UV-B exposure (Klein et al. 2004).
AMD Binding (cause) of associated with age-related macular degeneration
9) Confidence 0.30 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.78 Pain Relevance 0.04
A clinical trial (CABERNET) of focal beta brachytherapy with strontium-90 delivered locally is expected to start patient recruitment soon to evaluate the safety and efficacy of this system in the treatment of subfoveal CNV associated with neovascular AMD.
AMD Binding (associated) of associated with age-related macular degeneration
10) Confidence 0.30 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 0.90 Pain Relevance 0
There are multiple risk factors associated with AMD (Nowak 2006).
AMD Binding (associated) of associated with age-related macular degeneration
11) Confidence 0.29 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.40 Pain Relevance 0.03
New discoveries, however, are beginning to provide a much clearer picture of the relevant cellular events, genetic factors, and biochemical processes associated with early AMD.
AMD Binding (associated) of associated with age-related macular degeneration
12) Confidence 0.27 Published 2006 Journal Ann. Med. Section Abstract Doc Link 17101537 Disease Relevance 1.20 Pain Relevance 0.08
Fourth, despite strong associations of AMD with genetic factors, we felt that genetic testing was not readily available in general clinical practice.
AMD Binding (associations) of associated with age-related macular degeneration
13) Confidence 0.22 Published 2010 Journal BMC Ophthalmol Section Body Doc Link PMC3009619 Disease Relevance 0.46 Pain Relevance 0.07
Of the 16 risk factors identified in our systematic review and meta-analysis, age, current smoking, cataract surgery, and potentially family history were strongly and consistently associated with late AMD.
AMD Binding (associated) of associated with nicotine addiction, age-related macular degeneration and cataract
14) Confidence 0.22 Published 2010 Journal BMC Ophthalmol Section Body Doc Link PMC3009619 Disease Relevance 1.05 Pain Relevance 0
For articles that passed initial screen, additional criteria were applied for inclusion in the meta-analysis: 1) estimates for association with neovascular AMD and geographic atrophy were excluded when concomitantly presented as late AMD to avoid double counting; 2) for three epidemiological studies that examined the risk of late AMD (i.e., Beaver Dam [24-26], Blue Mountains [24-26], and Rotterdam [25,26]) both the original estimates and pooled estimates of the three studies exist.
AMD Binding (association) of associated with age-related macular degeneration and geographic atrophy
15) Confidence 0.22 Published 2010 Journal BMC Ophthalmol Section Body Doc Link PMC3009619 Disease Relevance 1.03 Pain Relevance 0
Supplemental zinc has been found to decrease the rate of loss of VA associated with AMD [16].
AMD Binding (associated) of associated with age-related macular degeneration
16) Confidence 0.17 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1831760 Disease Relevance 0.90 Pain Relevance 0
Increasing age, current cigarette smoking, previous cataract surgery, and a family history of AMD showed strong and consistent associations with late AMD.
AMD Binding (associations) of associated with nicotine addiction, age-related macular degeneration and cataract
17) Confidence 0.16 Published 2010 Journal BMC Ophthalmol Section Abstract Doc Link PMC3009619 Disease Relevance 1.64 Pain Relevance 0
Our meta-analysis confirmed the increased risks of late AMD associated with advancing age (especially for the oldest age groups of 80 years and over), current cigarette smoking, and previous cataract surgery.
AMD Binding (associated) of associated with nicotine addiction, age-related macular degeneration and cataract
18) Confidence 0.16 Published 2010 Journal BMC Ophthalmol Section Body Doc Link PMC3009619 Disease Relevance 1.50 Pain Relevance 0
Findings from the meta-analysis show an insignificant association between family history and late AMD (OR 6.18; 95% CI 1.94 - 6.61).
AMD Binding (association) of associated with age-related macular degeneration
19) Confidence 0.16 Published 2010 Journal BMC Ophthalmol Section Body Doc Link PMC3009619 Disease Relevance 0.43 Pain Relevance 0
Cardiovascular risk factors are also associated with AMD.
AMD Binding (associated) of associated with age-related macular degeneration
20) Confidence 0.16 Published 2010 Journal BMC Ophthalmol Section Abstract Doc Link PMC3009619 Disease Relevance 1.51 Pain Relevance 0

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