INT139872

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 7.69
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 11
spinal cords 1
brain 1
neurite 1
hippocampus 1
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 26 99.74 Very High Very High Very High
fluoxetine 8 98.64 Very High Very High Very High
Bile 3 98.32 Very High Very High Very High
Abeta 5 95.12 Very High Very High Very High
Inflammatory response 29 94.84 High High
Chronic pancreatitis 5 94.64 High High
Potency 4 94.40 High High
glial activation 4 84.64 Quite High
Spinal cord 66 84.44 Quite High
cINOD 86 81.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 197 99.72 Very High Very High Very High
Stroke 9 99.18 Very High Very High Very High
Toxicity 8 98.36 Very High Very High Very High
Brain Disease 8 97.52 Very High Very High Very High
Neurodegenerative Disease 23 96.12 Very High Very High Very High
Stress Incontinence 2 95.52 Very High Very High Very High
Pancreatitis 5 94.64 High High
INFLAMMATION 129 94.44 High High
Disease 224 94.04 High High
Pruritus 4 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that chronic fluoxetine administration activates Notch1 signaling in the hippocampus, and the up-regulation of the Notch1 pathway brought about by chronic fluoxetine administration might partly contribute to increased neurogenesis in hippocampus.
Regulation (regulation) of Notch1 in hippocampus associated with hippocampus, neurodegenerative disease and fluoxetine
1) Confidence 0.45 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801843 Disease Relevance 0.46 Pain Relevance 0.90
The transplanted NSPCs can be affected by controlling the Notch level under in intact neonatal spinal cords.
Regulation (controlling) of Notch in spinal cords
2) Confidence 0.26 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.22 Pain Relevance 0.22
This was due to dose-dependent changes in expression at 6 h for several genes that control neurite branching and morphogenesis including Cxcl12, Notch1 and ?
Regulation (control) of Notch1 in neurite
3) Confidence 0.24 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.05 Pain Relevance 0.03
These findings suggest a possible role of the Notch pathway during pancreatic regeneration since Jagged-1 inhibits inducible collagen-1 production, suggesting a new mechanism of tissue repair in this disease.
Spec (possible) Regulation (role) of Notch in Notch associated with disease
4) Confidence 0.20 Published 2006 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17114010 Disease Relevance 0.62 Pain Relevance 0.55
Moreover, the importance of the proteolytic regulation of the Notch signaling network is emphasized.


Regulation (regulation) of Notch in Notch
5) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.32 Pain Relevance 0
Proteolysis mediated Notch signaling regulation
Regulation (regulation) of Notch in Notch
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.05 Pain Relevance 0
It is already known, that Notch signaling is highly regulated by ubiquitinylation (for review see [43]).
Regulation (regulated) of Notch in Notch
7) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.09 Pain Relevance 0
Moreover, the importance of the proteolytic regulation of the Notch signaling network emphasized.


Regulation (regulation) of Notch in Notch
8) Confidence 0.09 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2699037 Disease Relevance 0.38 Pain Relevance 0
However, due to the promiscuous substrate specificity of gamma-secretase and its essential role in the NOTCH signaling pathway overt mechanism-based toxicity has been observed in preclinical studies of gamma-secretase inhibitors.
Regulation (role) of NOTCH associated with toxicity
9) Confidence 0.04 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 17105431 Disease Relevance 0.78 Pain Relevance 0.42
secretase regulates maturation of T cells by regulating the Notch signaling pathway, whereas its inactivation causes side effects on immune function.
Regulation (regulating) of Notch in Notch
10) Confidence 0.04 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.90 Pain Relevance 0.23
Indeed irradiation activated the Notch pathway, as demonstrated by the expression of the Notch target genes Hey1, and its inhibition by the ?
Regulation (genes) of Notch in Notch
11) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.18 Pain Relevance 0
formation without affecting Notch [17].
Neg (without) Regulation (affecting) of Notch in Notch
12) Confidence 0.03 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604888 Disease Relevance 0.08 Pain Relevance 0.17
-secretase-mediated Notch signaling worsens brain damage during ischemic stroke, it has been suggested that agents that target Notch function may be useful for therapeutic interventions in some brain disorders (Lathia et al., 2008).
Regulation (target) of Notch in brain associated with brain disease and stroke
13) Confidence 0.03 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.64 Pain Relevance 0.12
-secretase level with little or no effect on Notch proteolysis.
Neg (little) Regulation (effect) of Notch in Notch
14) Confidence 0.03 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604888 Disease Relevance 0.09 Pain Relevance 0.20
Notch activity has been shown to regulate granule-cell progenitors from which MBs arise, with Notch2 gene copy numbers increased in 15% of MBs [12], [20].
Regulation (regulate) of Notch in Notch associated with cancer
15) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 1.13 Pain Relevance 0
This may well be due to the extremely high motility of Daoy cells, indicating that to overcome this phenotype, a further step beyond regulation of the Notch pathway needs to take place.
Regulation (regulation) of Notch in Notch
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.70 Pain Relevance 0

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