INT139885

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 1.46
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES) signal transduction (PTGES) cytoplasm (PTGES)
Anatomy Link Frequency
HMSM 2
chondrocytes 1
mesenchymal cells 1
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 308 99.84 Very High Very High Very High
cytokine 26 99.28 Very High Very High Very High
antagonist 2 79.32 Quite High
cINOD 18 77.28 Quite High
Inflammation 120 76.04 Quite High
Dismenorea 1 73.80 Quite High
alcohol 7 39.08 Quite Low
COX2 4 25.00 Low Low
metalloproteinase 49 5.00 Very Low Very Low Very Low
licofelone 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 336 99.84 Very High Very High Very High
Apoptosis 7 82.24 Quite High
INFLAMMATION 157 76.72 Quite High
Dysmenorrhea 1 73.80 Quite High
Disease 21 5.00 Very Low Very Low Very Low
Arthritis 14 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Osteophyte 7 5.00 Very Low Very Low Very Low
Necrosis 7 5.00 Very Low Very Low Very Low
Adhesions 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have determined (i) the immuno-localization of all three PGES enzymes in lower segment pregnant human myometrium, (ii) the expression of PGES and COX-2 mRNA expression at term and preterm gestation with and without labour and (iii) the effect of interleukin (IL)-1beta on COX-2 and PGES mRNA and protein expression in human myometrial smooth muscle (HMSM) cell cultures.
Transcription (expression) of PGES in HMSM
1) Confidence 0.68 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.07 Pain Relevance 0.18
We hypothesized that the induction of Egr-1 activity by HNE could be the mechanism by which HNE exerts its stimulatory effect on mPGES-1 transcription.
Transcription (transcription) of mPGES-1
2) Confidence 0.63 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.23 Pain Relevance 0.16
M HNE to cultures significantly increased mPGES-1 protein and mRNA levels, which plateaued at 16 hours but then declined at 24 hours (Figure 2a, c). mPGES-1 protein and mRNA reached maximum levels of 230 and 220% of control values, respectively (P < 0.01).
Transcription (levels) of mPGES-1 protein
3) Confidence 0.63 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.16 Pain Relevance 0.05
The maximum levels of mPGES-1 protein and mRNA were 400 and 300% of the controls, respectively (P < 0.001).
Transcription (levels) of mPGES-1 protein
4) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.13 Pain Relevance 0.04
M HNE to cultures significantly increased mPGES-1 protein and mRNA levels, which plateaued at 16 hours but then declined at 24 hours (Figure 2a, c). mPGES-1 protein and mRNA reached maximum levels of 230 and 220% of control values, respectively (P < 0.01).
Transcription (reached) of mPGES-1 protein
5) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.15 Pain Relevance 0.04
To gain insights into the role of HNE in the mechanism underlying the production of PGE2 we evaluated its effect on the protein and mRNA expression of mPGES-1, an inducible form of PGES involved in the terminal step of PGE2 synthesis.
Transcription (expression) of mPGES-1
6) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.18 Pain Relevance 0.05
Collectively, these data suggest the involvement of this transcription factor in HNE-induced transcriptional activity of the mPGES-1 promoter in OA chondrocytes.
Transcription (activity) of mPGES-1 promoter in chondrocytes associated with osteoarthritis
7) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.18 Pain Relevance 0.13
M HNE, however, enhanced mPGES-1 protein and mRNA levels and plateaued at 24 hours (Figure 2b, c).
Transcription (levels) of mPGES-1 protein
8) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.13 Pain Relevance 0.04
We have determined (i) the immuno-localization of all three PGES enzymes in lower segment pregnant human myometrium, (ii) the expression of PGES and COX-2 mRNA expression at term and preterm gestation with and without labour and (iii) the effect of interleukin (IL)-1beta on COX-2 and PGES mRNA and protein expression in human myometrial smooth muscle (HMSM) cell cultures.
Transcription (expression) of PGES in HMSM
9) Confidence 0.53 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.08 Pain Relevance 0.19
With amnion mesenchymal cells, we found that proinflammatory cytokines coordinately upregulated PTGS2 and PTGES mRNA expression.
Transcription (expression) of PTGES in mesenchymal cells associated with cytokine
10) Confidence 0.50 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.15 Pain Relevance 0.25

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