INT139886

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 1.50
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (PTGES3) isomerase activity (PTGES3) small molecule metabolic process (PTGES3)
cytoplasm (PTGES3) cytosol (PTGES3) cell proliferation (PTGES3)
PTGES3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 61 93.68 High High
Inflammation 207 91.44 High High
antagonist 3 90.60 High High
cINOD 20 88.56 High High
Inflammatory stimuli 14 75.28 Quite High
Dismenorea 1 68.92 Quite High
rheumatoid arthritis 21 58.80 Quite High
COX-2 inhibitor 3 55.68 Quite High
Inflammatory response 7 31.24 Quite Low
Inflammatory mediators 23 27.24 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 253 91.44 High High
Apoptosis 14 84.52 Quite High
Dysmenorrhea 1 68.92 Quite High
Stomach Cancer 7 61.84 Quite High
Periodontitis 119 60.96 Quite High
Rheumatoid Arthritis 21 58.80 Quite High
Disease 56 48.92 Quite Low
Periodontal Disease 21 41.28 Quite Low
Hypercalcemia 14 36.80 Quite Low
Tooth Loss 7 18.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostaglandin E(2) (PGE(2)) is synthesized by one of three enzymes, cytosolic prostaglandin E synthase (cPGES), microsomal PGES-1 (mPGES-1) and microsomal PGES-2 (mPGES-2).
Gene_expression (synthesized) of cPGES
1) Confidence 0.72 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.09 Pain Relevance 0.22
Expression of mPGES-2 mRNA increased with term labour and PTL and expression of COX-2 and mPGES-1 mRNA with term labour, whereas cPGES expression did not change.
Gene_expression (expression) of cPGES
2) Confidence 0.63 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.05 Pain Relevance 0.13
Prostaglandin E(2) (PGE(2)) is synthesized by one of three enzymes, cytosolic prostaglandin E synthase (cPGES), microsomal PGES-1 (mPGES-1) and microsomal PGES-2 (mPGES-2).
Gene_expression (synthesized) of cytosolic prostaglandin E synthase
3) Confidence 0.55 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.09 Pain Relevance 0.22
In comparison, the expression of two other PGE synthases (PTGES2 and PTGES3) was unmodified.
Gene_expression (expression) of PTGES3
4) Confidence 0.49 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.14 Pain Relevance 0.23
On the contrary, the PGE synthase isoenzymes mPGES-2 and cPGES were not differentially expressed at the above-mentioned time points (Figure 2), which is consistent with the protein expression results.
Neg (not) Gene_expression (expressed) of cPGES
5) Confidence 0.30 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0 Pain Relevance 0
-treated cells in contrast to mPGES-2 and cPGES expression (Figure 1B).
Gene_expression (expression) of cPGES
6) Confidence 0.30 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.06 Pain Relevance 0.03
For each sample, 10 000 events were acquired and cells were analyzed regarding the expression of mPGES-1, mPGES-2, cPGES or COX-2.
Spec (analyzed) Gene_expression (expression) of cPGES
7) Confidence 0.30 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0 Pain Relevance 0
Primary EM cultures from all 10 donors expressed cPLA2, COX-1, cPGES, mPGES-1 and mPGES-2 proteins (Figure 2A).
Gene_expression (expressed) of cPGES
8) Confidence 0.27 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0 Pain Relevance 0.03
Up to date, three PGE synthases have been described: The microsomal and inducible mPGES-1, the constitutively expressed cytosolic cPGES and the most recently discovered microsomal mPGES-2 [25-29].
Gene_expression (expressed) of cPGES
9) Confidence 0.26 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.64 Pain Relevance 0.23
In contrast to the mPGES-1 and COX-2 enzymes, the expression of the PGE synthases mPGES-2 and cPGES was not affected by TNF?
Gene_expression (expression) of cPGES
10) Confidence 0.23 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.25 Pain Relevance 0.08
The mRNA expression of mPGES-1, mPGES-2, cPGES and COX-2, as measured by oligonucleotide microarray, is seen in Figure 2.
Gene_expression (expression) of cPGES
11) Confidence 0.23 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.05 Pain Relevance 0.03
In contrast to mPGES-1 and COX-2, the expression of the PGE synthase isoenzymes mPGES-2 and cPGES was not affected by TNF?
Gene_expression (expression) of cPGES
12) Confidence 0.23 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.13 Pain Relevance 0.07

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