INT139894

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 0.36
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Msn) nucleolus (Msn) plasma membrane (Msn)
cytoskeleton (Msn) nucleus (Msn) protein binding, bridging (Msn)
Anatomy Link Frequency
MSN 4
spike 2
lateral 1
Msn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 504 100.00 Very High Very High Very High
projection neuron 95 100.00 Very High Very High Very High
Enkephalin 79 100.00 Very High Very High Very High
Dopamine 516 99.98 Very High Very High Very High
Action potential 83 99.42 Very High Very High Very High
withdrawal 9 99.20 Very High Very High Very High
narcan 1 98.82 Very High Very High Very High
substance P 49 98.32 Very High Very High Very High
Neuropeptide 1 97.20 Very High Very High Very High
Nucleus accumbens 464 90.92 High High
Disease Link Frequency Relevance Heat
Drug Dependence 7 85.08 High High
Disease 5 82.72 Quite High
Parkinson's Disease 31 76.48 Quite High
Cognitive Disorder 5 58.48 Quite High
Decapitation 15 5.00 Very Low Very Low Very Low
Hypersensitivity 15 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Respiratory Tract Infection 5 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To explain how a depolarizing input enhances depolarization when it is blocked, one has to assume that inhibition in D2-ENK+ MSNs is restraining intrinsic depolarizing currents (shunting inhibition) even at subthreshold levels (Carter and Sabatini, 2004; Day et al., 2008) supporting the assumption made above.
Negative_regulation (inhibition) of MSN associated with projection neuron and enkephalin
1) Confidence 0.41 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.65
Moreover the action potential threshold was significantly decreased in MSN from dopamine-depleted rats (?
Negative_regulation (decreased) of MSN associated with action potential and dopamine
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.08 Pain Relevance 0.35
Our analysis shows that both spontaneous and naloxone-induced withdrawal produces a long-lasting but reversible reduction in spines' density in shell MSN, as compared with core MSN.
Negative_regulation (reduction) of MSN in MSN associated with narcan and withdrawal
3) Confidence 0.38 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105943 Disease Relevance 0 Pain Relevance 0.89
In this way, lateral inhibition between MSN would support a ‘winner take all’ mechanism in the selection of striatal outputs.
Negative_regulation (inhibition) of MSN in lateral associated with pyramidal cell
4) Confidence 0.36 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.65
Relationships of MSN recurrent axon collaterals with subregional and compartmental boundaries and with the dendritic arborizations
Negative_regulation (Relationships) of MSN associated with pyramidal cell
5) Confidence 0.36 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.22
Lateral inhibition between MSN is thought to play a role in the interactions between collections or ‘ensembles’ of neurons that are influenced by different sets of cortical inputs and code for competing outputs of the striatum (e.g., Pennartz et al. 1994; Plenz 2003; Tepper et al. 2004).
Negative_regulation (inhibition) of MSN in neurons associated with pyramidal cell
6) Confidence 0.36 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.63
However, despite series of available data [5], [6] the effects resulting from dopamine depletion on the MSN intrinsic excitability remain incompletely documented and puzzling.
Negative_regulation (depletion) of MSN in MSN associated with dopamine
7) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.23 Pain Relevance 0.39
The first spike latency in the 120 pA-evoked spike response was significantly decreased in MSN from 6-OHDA lesioned rats (0.313±0.07 ms for unlesioned control animals, n?
Negative_regulation (decreased) of MSN in spike
8) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.06 Pain Relevance 0
Moreover, when suprathreshold EPSPs (Fig. 6Fa,b) were examined, it appeared that the spike threshold was also decreased in dopamine-depleted MSN (?
Negative_regulation (depleted) of MSN in spike associated with dopamine
9) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.36
7, p<0.05; Fig. 3F,G) and the action potential threshold was significantly decreased in MSN from 6-OHDA lesioned rats (?
Negative_regulation (decreased) of MSN associated with action potential
10) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.18
Consistent with its expression in a majority of striatal MSN, PDE10A inhibition significantly induces expression of both substance P and enkephalin, neuropeptide markers for the direct and indirect striatal output pathways, respectively.
Negative_regulation (inhibition) of MSN in MSN associated with neuropeptide, enkephalin and substance p
11) Confidence 0.03 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 19765598 Disease Relevance 0 Pain Relevance 0.20

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