INT139898

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 4.66
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
neurons 4
hepatocytes 2
liver 2
epithelial cells 2
DRG 2
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 133 100.00 Very High Very High Very High
Bile 61 100.00 Very High Very High Very High
Morphine 10 100.00 Very High Very High Very High
Dopamine 138 99.48 Very High Very High Very High
Spinal cord 6 99.28 Very High Very High Very High
intrathecal 2 99.22 Very High Very High Very High
antagonist 74 97.32 Very High Very High Very High
agonist 80 96.68 Very High Very High Very High
imagery 34 96.48 Very High Very High Very High
analgesia 20 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 10 98.62 Very High Very High Very High
Hyperglycemia 12 98.60 Very High Very High Very High
Diabetes Mellitus 101 97.54 Very High Very High Very High
Rheumatoid Arthritis 5 95.48 Very High Very High Very High
Stress 31 94.96 High High
Cv General 4 Under Development 4 93.36 High High
Neuropathic Pain 5 93.00 High High
Toxicity 12 92.40 High High
Renal Disease 4 90.24 High High
Pain 15 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, resveratrol attenuated cell death in organotypic hippocampal slice cultures exposed to oxygen-glucose deprivation through activation of the phosphoinositide-3-kinase (PI3-K)/Akt pathway [17].
Negative_regulation (deprivation) of Positive_regulation (activation) of Akt associated with death
1) Confidence 0.42 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.99 Pain Relevance 0.18
Immunohistochemistry revealed that intrathecal injection of wortmannin significantly inhibited the activation of PKB/Akt in L5 DRG and L5 spinal cord.
Negative_regulation (inhibited) of Positive_regulation (activation) of Akt in DRG associated with spinal cord and intrathecal
2) Confidence 0.42 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17628541 Disease Relevance 0.56 Pain Relevance 0.90
In contrast, inhibition of 5-HT-mediated RhoA degradation by MG132 prevented 5-HT-induced Akt activation.
Negative_regulation (prevented) of Positive_regulation (activation) of Akt
3) Confidence 0.40 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.22
Wortmannin blocked FBF, MXD, and liver P-Akt/Akt increases from 10 mU.min-1.kg-1 insulin.
Negative_regulation (blocked) of Positive_regulation (increases) of Akt in liver
4) Confidence 0.37 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17106063 Disease Relevance 0.51 Pain Relevance 0.06
CONCLUSIONS—Hyperglycemia in type 1 diabetes and treatment of proximal tubular epithelial cells with high glucose leads to phosphorylation/inactivation of tuberin and downregulation of OGG1 via a redox-dependent activation of Akt in renal tubular epithelial cells.
Negative_regulation (downregulation) of Positive_regulation (activation) of Akt in epithelial cells associated with hyperglycemia and diabetes mellitus
5) Confidence 0.35 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551671 Disease Relevance 0.38 Pain Relevance 0
In summary, our data provide the first evidence that hyperglycemia and high glucose lead to phosphorylation/inactivation of tuberin and downregulation of DNA repair enzyme OGG1 via the redox-dependent activation of Akt (Fig. 9).
Negative_regulation (downregulation) of Positive_regulation (activation) of Akt associated with hyperglycemia
6) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.60 Pain Relevance 0
The DADLE-dependent increases in Akt and ERK1/2 phosphorylation were abolished by either MPI or AG1478, confirming a signaling through the EGFR pathway.
Negative_regulation (abolished) of Positive_regulation (increases) of Akt
7) Confidence 0.34 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17545478 Disease Relevance 0.27 Pain Relevance 0.41
Our finding, that treatment with IBMX reduced levels of activated Akt in hippocampal neurons after 15 minutes, fits within the proposed temporal window of the actions of cAMP signals [11].
Negative_regulation (reduced) of Positive_regulation (activated) of Akt in neurons
8) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0 Pain Relevance 0.09
We have previously reported that activation of the AKT and ERK1/2 pathways by conjugated bile acids in primary hepatocytes is through a PTX/dominant negative G?
Negative_regulation (is) of Positive_regulation (activation) of AKT in hepatocytes associated with bile
9) Confidence 0.25 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.22 Pain Relevance 0.37
SKNMCs express KATP channels subunits: glibenclamide inhibits MOR activation and AKT phosphorylation
Negative_regulation (inhibits) of Positive_regulation (activation) of AKT associated with opioid receptor
10) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.45
When neurons were treated with dopamine alone (30 nM), levels of activated Akt (pAkt) decreased by 50% (Fig. 7A, B).
Negative_regulation (decreased) of Positive_regulation (activated) of pAkt in neurons associated with dopamine
11) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0.06 Pain Relevance 0.58
H9C2 cells raised in 25 mmol/l compared with 5.56 mmol/l glucose media also demonstrated reduced morphine-induced P-GSK3beta, P-Akt, P-STAT3, and P-ERK1 after 15 min.
Negative_regulation (reduced) of Positive_regulation (morphine-induced) of P-Akt associated with morphine
12) Confidence 0.13 Published 2007 Journal Diabetes Section Abstract Doc Link 17192474 Disease Relevance 0.54 Pain Relevance 0.59
FBS- and PDGF-BB-stimulated intracellular Ras, MEK1/2, ERK1/2, proliferative cell nuclear antigen (PCNA), and Akt activations were significantly inhibited by lercanidipine; however, lercanidipine did not affect FBS- and PDGF-BB-induced STAT3 phosphorylation.
Negative_regulation (inhibited) of Positive_regulation (activations) of Akt
13) Confidence 0.08 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 18973813 Disease Relevance 0.41 Pain Relevance 0.14
Hence, we tested the phosphorylation status of Akt upon stimulation with LPS/A?
Negative_regulation (tested) of Positive_regulation (status) of Akt
14) Confidence 0.08 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.07 Pain Relevance 0.06
In contrast, isolating the unsaponifiable fraction from argan oil C1 extract yielded the loss of enhanced Akt activation but was characterized with a powerful inhibitory action at the level of ERK1/2.
Negative_regulation (loss) of Positive_regulation (activation) of Akt
15) Confidence 0.03 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513146 Disease Relevance 0.06 Pain Relevance 0

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