INT139901

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.58
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Ins1, Akt1) cytoplasm (Ins1, Akt1) nucleoplasm (Akt1)
transport (Akt1) aging (Akt1) enzyme binding (Akt1)
Anatomy Link Frequency
aorta 2
liver 2
muscle 2
Ins1 (Rattus norvegicus)
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 1 100.00 Very High Very High Very High
agonist 6 86.96 High High
anesthesia 11 73.88 Quite High
Bile 61 70.08 Quite High
cytokine 1 49.12 Quite Low
Inflammation 6 48.72 Quite Low
fibrosis 14 22.80 Low Low
imagery 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 1 100.00 Very High Very High Very High
Rheumatoid Arthritis 30 99.40 Very High Very High Very High
Diabetes Mellitus 62 99.28 Very High Very High Very High
Hyperinsulinism 7 95.96 Very High Very High Very High
Hyperplasia 4 93.48 High High
Left Ventricular Hypertrophy 1 91.88 High High
Coronary Heart Disease 10 84.88 Quite High
Hypertrophy 14 81.12 Quite High
Myocardial Infarction 78 80.16 Quite High
Cardiovascular Disease 2 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin (10 and 20 mU.min-1.kg-1) increased FBF, MXD, GIR, Rd, and HLGU as well as liver, muscle, and aorta P-Akt/Akt and decreased Ra (all P<0.05).
Insulin Positive_regulation (increased) of Akt in aorta associated with rheumatoid arthritis
1) Confidence 0.31 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17106063 Disease Relevance 0.49 Pain Relevance 0.07
Insulin (10 and 20 mU.min-1.kg-1) increased FBF, MXD, GIR, Rd, and HLGU as well as liver, muscle, and aorta P-Akt/Akt and decreased Ra (all P<0.05).
Insulin Positive_regulation (increased) of Akt in aorta associated with rheumatoid arthritis
2) Confidence 0.29 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17106063 Disease Relevance 0.49 Pain Relevance 0.07
Insulin (10 and 20 mU.min-1.kg-1) increased FBF, MXD, GIR, Rd, and HLGU as well as liver, muscle, and aorta P-Akt/Akt and decreased Ra (all P<0.05).
Insulin Positive_regulation (increased) of Akt in muscle associated with rheumatoid arthritis
3) Confidence 0.11 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17106063 Disease Relevance 0.49 Pain Relevance 0.07
Insulin (10 and 20 mU.min-1.kg-1) increased FBF, MXD, GIR, Rd, and HLGU as well as liver, muscle, and aorta P-Akt/Akt and decreased Ra (all P<0.05).
Insulin Positive_regulation (increased) of Akt in liver associated with rheumatoid arthritis
4) Confidence 0.11 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17106063 Disease Relevance 0.49 Pain Relevance 0.07
Insulin, TCA, and DCA all significantly activated the AKT-1 isoform.
Insulin Positive_regulation (activated) of AKT-1 isoform
5) Confidence 0.10 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.12 Pain Relevance 0.06
Insulin (10 and 20 mU.min-1.kg-1) increased FBF, MXD, GIR, Rd, and HLGU as well as liver, muscle, and aorta P-Akt/Akt and decreased Ra (all P<0.05).
Insulin Positive_regulation (increased) of Akt in liver associated with rheumatoid arthritis
6) Confidence 0.10 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17106063 Disease Relevance 0.49 Pain Relevance 0.07
Insulin (10 and 20 mU.min-1.kg-1) increased FBF, MXD, GIR, Rd, and HLGU as well as liver, muscle, and aorta P-Akt/Akt and decreased Ra (all P<0.05).
Insulin Positive_regulation (increased) of Akt in muscle associated with rheumatoid arthritis
7) Confidence 0.10 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17106063 Disease Relevance 0.49 Pain Relevance 0.07
Insulin and angiotensin II are known to activate the PI3K/Akt/mTOR/P70S6K pathways and to phosphorylate 4E-BP1.13-15
Insulin Positive_regulation (activate) of Akt
8) Confidence 0.07 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.37 Pain Relevance 0.04
The Akt kinase pathway is activated by various stressful stimuli such as ischemia, heat, angiotensin II and circulating insulin.
insulin Positive_regulation (activated) of Akt kinase associated with ischemia
9) Confidence 0.04 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.13 Pain Relevance 0.05

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