INT139929

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.67
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
plasma membrane (Ngfr) nucleus (Ngfr) cytoplasm (Ngfr)
Anatomy Link Frequency
neurons 1
Nerve 1
brain 1
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 4 96.68 Very High Very High Very High
TRP channel 1 82.00 Quite High
dorsal root ganglion 3 78.72 Quite High
Cold hyperalgesia 1 66.48 Quite High
neuralgia 3 25.00 Low Low
Eae 1 20.16 Low Low
Bile 14 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 3 99.00 Very High Very High Very High
Neuropathic Pain 4 96.68 Very High Very High Very High
Injury 1 92.96 High High
Adhesions 5 91.12 High High
Death 1 85.40 High High
Body Weight 10 81.60 Quite High
Disease 64 80.32 Quite High
Ganglion Cysts 3 77.76 Quite High
Obesity 3 69.44 Quite High
Cognitive Disorder 1 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nerve injury increased the expression and axonal transport of p75NTR and phosphorylation of TrkA in the uninjured primary afferents.
Phosphorylation (phosphorylation) of p75NTR in Nerve associated with nervous system injury
1) Confidence 0.58 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17108171 Disease Relevance 0.96 Pain Relevance 0.57
TrkB is a membrane-bound neurotrophin receptor that phosphorylates itself, and members of the MAPK pathway, after binding of its ligand; the brain-derived neurotrophin (Bdnf) [28], [29].
Phosphorylation (phosphorylates) of neurotrophin receptor in brain
2) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.47 Pain Relevance 0
For example, complex oligosaccharide modification and brain-derived neurotrophic factor-induced phosphorylation of the neurotrophin receptor TrkB was severely affected in neurons lacking PS1 expression [93].
Phosphorylation (phosphorylation) of neurotrophin receptor in neurons
3) Confidence 0.04 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.24 Pain Relevance 0

General Comments

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