INT139930

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 35
Total Number 37
Disease Relevance 6.22
Pain Relevance 8.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a7) transmembrane transport (Slc17a7)
Anatomy Link Frequency
neurons 3
thalamus 3
glutamatergic neurons 3
cortex 2
spinal cord 1
Slc17a7 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 541 100.00 Very High Very High Very High
Hippocampus 172 100.00 Very High Very High Very High
Thalamus 108 99.60 Very High Very High Very High
GABAergic 384 98.80 Very High Very High Very High
medulla 72 97.76 Very High Very High Very High
Spinal cord 103 97.20 Very High Very High Very High
Eae 65 97.12 Very High Very High Very High
Sciatic nerve 2 95.32 Very High Very High Very High
midbrain 5 94.48 High High
qutenza 2 93.92 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 433 99.20 Very High Very High Very High
Infection 185 98.36 Very High Very High Very High
Nociception 56 97.48 Very High Very High Very High
Inflammatory Pain 29 97.12 Very High Very High Very High
Nervous System Injury 56 93.40 High High
Neuropathic Pain 115 90.12 High High
Hypoglycemia 78 77.88 Quite High
Pain 78 74.64 Quite High
Convulsion 40 70.64 Quite High
Increased Venous Pressure Under Development 33 66.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VGLUT1 (Slc17a7) and VGLUT2 (Slc17a6) are expressed in glutamatergic neurons, while VGLUT3 (Slc17a8) is expressed in neurons classically defined by their use of another transmitter, such as acetylcholine and serotonin.
Gene_expression (expressed) of VGLUT1 in neurons associated with serotonin
1) Confidence 0.75 Published 2010 Journal Upsala Journal of Medical Sciences Section Abstract Doc Link PMC2853350 Disease Relevance 0 Pain Relevance 0.33
For example, the switch from VGLUT2 to VGLUT1 expression was observed in vivo by both Fremeau et al. and Wojcik et al. in 2004, when they genetically deleted VGLUT1 expression in mice using full knockout strategies (12,13).
Gene_expression (expression) of VGLUT1 associated with targeted disruption
2) Confidence 0.75 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.10 Pain Relevance 0.24
The Vglut1-/- mice survived 2 weeks after birth, but as the VGLUT1 expression increased during the third postnatal week in the wild-type animals, the Vglut1-/- mice started to die.
Gene_expression (expression) of VGLUT1
3) Confidence 0.75 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.10 Pain Relevance 0.23
For example, the switch from VGLUT2 to VGLUT1 expression was observed in vivo by both Fremeau et al. and Wojcik et al. in 2004, when they genetically deleted VGLUT1 expression in mice using full knockout strategies (12,13).
Gene_expression (expression) of VGLUT1 associated with targeted disruption
4) Confidence 0.75 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.09 Pain Relevance 0.23
VGLUT1 (Slc17a7) and VGLUT2 (Slc17a6) are expressed in glutamatergic neurons, while VGLUT3 (Slc17a8) is expressed in neurons classically defined by their use of another transmitter, such as acetylcholine and serotonin.
Gene_expression (expressed) of Slc17a7 in neurons associated with serotonin
5) Confidence 0.75 Published 2010 Journal Upsala Journal of Medical Sciences Section Abstract Doc Link PMC2853350 Disease Relevance 0 Pain Relevance 0.33
As the distribution of VGLUT1 and 2 differs between brain regions, the authors performed electrophysiological studies on cells isolated both from the hippocampus (with high VGLUT1 expression) and the thalamus (with high VGLUT2 expression) from wild-type and Vglut2-/- mice respectively.
Gene_expression (expression) of VGLUT1 in thalamus associated with thalamus and hippocampus
6) Confidence 0.75 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.27 Pain Relevance 0.18
Their expression pattern is to a large extent complementary, with VGLUT1 mainly expressed in the cerebral and cerebellar cortex and hippocampus, and VGLUT2 mainly expressed in deeper brain regions including the thalamus and the brainstem (for an example of Vglut2 mRNA expression, see Figure 1, which was produced in our laboratory by digoxigenin-labelled in situ hybridization on vibratome-sliced sections) (7,9,10).
Gene_expression (expressed) of VGLUT1 in brain associated with medulla, thalamus and hippocampus
7) Confidence 0.75 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0 Pain Relevance 0.46
Acute nociception was unchanged in Vglut2+/- mice, which indicates that the glutamatergic signalling in the nociceptive pathway is independent of VGLUT2, unaffected by the 50% decrease in VGLUT2 levels, or compensated by an increased peripheral VGLUT1 expression.
Gene_expression (expression) of VGLUT1 associated with nociception
8) Confidence 0.66 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.89 Pain Relevance 0.68
Based on gene expression analysis, it is clear that the majority of neurons in the postnatal cortex and hippocampus predominantly express VGLUT1 (7,9,10,15,30–32).
Gene_expression (express) of VGLUT1 in cortex associated with hippocampus
9) Confidence 0.66 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.20 Pain Relevance 0.23
Interestingly, this complete knockout of VGLUT2 was not compensated for by an increase in VGLUT1 levels, also shown by Western blot analysis.
Gene_expression (levels) of VGLUT1 associated with targeted disruption
10) Confidence 0.65 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.41 Pain Relevance 0.15
Their expression pattern is to a large extent complementary, with VGLUT1 mainly expressed in the cerebral and cerebellar cortex and hippocampus, and VGLUT2 mainly expressed in deeper brain regions including the thalamus and the brainstem (for an example of Vglut2 mRNA expression, see Figure 1, which was produced in our laboratory by digoxigenin-labelled in situ hybridization on vibratome-sliced sections) (7,9,10).
Gene_expression (expressed) of VGLUT1 in thalamus associated with medulla, thalamus and hippocampus
11) Confidence 0.58 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0 Pain Relevance 0.47
A fundamental step forward for the research field around glutamate came with the recent identification that three members of the solute carrier family, Slc17a6–8, act as vesicular glutamate transporters (and were hence named VGLUT1, 2, 3).
Gene_expression (named) of VGLUT1 associated with glutamate
12) Confidence 0.57 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.42 Pain Relevance 0.51
Three transporters (VGLUT1-VGLUT3) are expressed in the mammalian CNS, with partial overlapping expression patterns, and VGLUT2 is the most abundantly expressed paralog in the thalamus, midbrain, and brainstem.
Gene_expression (expressed) of VGLUT1 in brainstem associated with medulla, midbrain and thalamus
13) Confidence 0.56 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17108179 Disease Relevance 0.07 Pain Relevance 0.39
The mean percentage of colocalized area of VGluT1 and GFP over the entire area of GFP in each cell was 0.2 (±0.05; number of cells?
Gene_expression (over) of VGluT1
14) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0.06 Pain Relevance 0.05
The negative control was obtained by measuring the percentage of GFP area in the granular layer (Golgi axon) that overlapped with VGluT1 in the rosette (mossy fiber terminal).
Gene_expression (overlapped) of VGluT1 in mossy fiber
15) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0 Pain Relevance 0
VGLUT1 is mainly expressed in corticogeniculate axon terminals [31], [32], but is not expressed in RGCs [36].
Gene_expression (expressed) of VGLUT1
16) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
VGLUT1 is mainly expressed in corticogeniculate axon terminals [31], [32], but is not expressed in RGCs [36].
Neg (not) Gene_expression (expressed) of VGLUT1
17) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
We measured the mean density of spines and counted the spines that coincided with VGluT1 expression (Fig. 6G).
Gene_expression (expression) of VGluT1 in spines
18) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0.12 Pain Relevance 0
As before, we confirmed the purity of the selected GABAergic and glutamatergic neuron samples using qRT-PCR analysis of VGLUT1/VGAT expression (Table 1).
Gene_expression (expression) of VGLUT1 in glutamatergic neuron associated with gabaergic
19) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0.06 Pain Relevance 0.35
In addition, the expression of the vesicular glutamate transporters, VGLUT1 and VGLUT2, was strongly reduced in synapsin II knockout mice in the spinal cord.
Gene_expression (expression) of VGLUT1 in spinal cord associated with targeted disruption, glutamate and spinal cord
20) Confidence 0.39 Published 2008 Journal Pain Section Abstract Doc Link 18701217 Disease Relevance 0.92 Pain Relevance 1.32

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