INT139935

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 36
Total Number 38
Disease Relevance 8.43
Pain Relevance 10.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a6) transmembrane transport (Slc17a6)
Anatomy Link Frequency
neurons 6
brain 4
thalamus 3
spinal cord 2
striatum 2
Slc17a6 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 1099 100.00 Very High Very High Very High
Hippocampus 244 100.00 Very High Very High Very High
Thalamus 214 99.76 Very High Very High Very High
amygdala 60 99.72 Very High Very High Very High
medulla 154 99.52 Very High Very High Very High
neuralgia 12 99.36 Very High Very High Very High
Spinal cord 216 99.28 Very High Very High Very High
cerebral cortex 60 98.96 Very High Very High Very High
midbrain 4 98.96 Very High Very High Very High
addiction 30 98.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 420 100.00 Very High Very High Very High
Targeted Disruption 906 99.96 Very High Very High Very High
Neuropathic Pain 253 98.68 Very High Very High Very High
Nervous System Injury 124 93.40 High High
Hypoglycemia 180 92.72 High High
Epilepsy 210 91.08 High High
Pain 180 90.56 High High
Disease 300 87.32 High High
Schizophrenia 270 85.60 High High
Diabetes Mellitus 60 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three transporters (VGLUT1-VGLUT3) are expressed in the mammalian CNS, with partial overlapping expression patterns, and VGLUT2 is the most abundantly expressed paralog in the thalamus, midbrain, and brainstem.
Gene_expression (expressed) of VGLUT2 in brainstem associated with medulla, midbrain and thalamus
1) Confidence 0.78 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17108179 Disease Relevance 0.07 Pain Relevance 0.40
Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain.
Gene_expression (expression) of VGLUT2 associated with neuralgia, glutamate and neuropathic pain
2) Confidence 0.78 Published 2006 Journal J. Neurosci. Section Title Doc Link 17108179 Disease Relevance 0.38 Pain Relevance 0.83
In a recent study, a connection between VGLUT2 gene expression and ALS was shown, which specified a role for VGLUT2 in motor neuron survival.
Gene_expression (expression) of VGLUT2 gene in motor neuron associated with motor neuron diseases
3) Confidence 0.78 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.51 Pain Relevance 0.20
VGLUT2 is indeed expressed in several brainstem nuclei involved in control of both respiration and cardiovascular function (15,16) and is thereby heavily implicated in life-supporting mechanisms.
Gene_expression (expressed) of VGLUT2 in brainstem associated with medulla
4) Confidence 0.78 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.08 Pain Relevance 0.18
VGLUT1 (Slc17a7) and VGLUT2 (Slc17a6) are expressed in glutamatergic neurons, while VGLUT3 (Slc17a8) is expressed in neurons classically defined by their use of another transmitter, such as acetylcholine and serotonin.
Gene_expression (expressed) of VGLUT2 in neurons associated with serotonin
5) Confidence 0.78 Published 2010 Journal Upsala Journal of Medical Sciences Section Abstract Doc Link PMC2853350 Disease Relevance 0 Pain Relevance 0.33
We have chosen to present the VGLUT2 mouse genetic studies in an order related to the extent of the deletion, i.e. full knockout studies come first, followed by conditional knockout studies, in which the deletion is complete in specifically selected neurons, and lastly heterozygote studies are presented, in which the entire organism has a reduction, but not complete deletion, of VGLUT2 expression.


Gene_expression (expression) of VGLUT2 in neurons associated with targeted disruption
6) Confidence 0.78 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.50 Pain Relevance 0.07
In addition, expression studies of motor neuron-specific markers, vesicular acetylcholine transporter and the high affinity choline transporter, demonstrated that motor neurons in the lumbar spinal cord were partly spared from degeneration by reduced VGLUT2 expression in Sod1G93A;Vglut2flox/+ mice.
Gene_expression (expression) of VGLUT2 in motor neuron associated with spinal cord
7) Confidence 0.78 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.47 Pain Relevance 0.23
VGLUT2 is not expressed in the striatum, but is expressed in a subset of the amygdaloid nuclei.
Neg (not) Gene_expression (expressed) of VGLUT2 in striatum
8) Confidence 0.78 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.05 Pain Relevance 0.25
VGLUT1 (Slc17a7) and VGLUT2 (Slc17a6) are expressed in glutamatergic neurons, while VGLUT3 (Slc17a8) is expressed in neurons classically defined by their use of another transmitter, such as acetylcholine and serotonin.
Gene_expression (expressed) of Slc17a6 in neurons associated with serotonin
9) Confidence 0.78 Published 2010 Journal Upsala Journal of Medical Sciences Section Abstract Doc Link PMC2853350 Disease Relevance 0 Pain Relevance 0.33
VGLUT2 is not expressed in the striatum, but is expressed in a subset of the amygdaloid nuclei.
Gene_expression (expressed) of VGLUT2 in striatum
10) Confidence 0.78 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.05 Pain Relevance 0.25
This dose-dependence can be studied using heterozygous knockout mice, having their VGLUT2 expression reduced by approximately 50%.
Gene_expression (expression) of VGLUT2 associated with targeted disruption and addiction
11) Confidence 0.68 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.53 Pain Relevance 0.20
However, a few cells in discrete regions of the cortex, such as in the retrosplenial group and the piriform cortex, as well as neurons in layers III and V/VI, do express certain levels of VGLUT2, as does the subiculum of the hippocampus.
Gene_expression (express) of VGLUT2 in neurons associated with hippocampus
12) Confidence 0.68 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.12 Pain Relevance 0.25
Their expression pattern is to a large extent complementary, with VGLUT1 mainly expressed in the cerebral and cerebellar cortex and hippocampus, and VGLUT2 mainly expressed in deeper brain regions including the thalamus and the brainstem (for an example of Vglut2 mRNA expression, see Figure 1, which was produced in our laboratory by digoxigenin-labelled in situ hybridization on vibratome-sliced sections) (7,9,10).
Gene_expression (expressed) of VGLUT2 in brain associated with medulla, thalamus and hippocampus
13) Confidence 0.68 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0 Pain Relevance 0.47
The respiratory central pattern generator (CPG) belongs to the better characterized CPGs, although before the production of VGLUT2 knockout mice it had been somewhat difficult to pin-point the role of glutamate signalling in this circuit.
Gene_expression (production) of VGLUT2 in respiratory associated with targeted disruption and glutamate
14) Confidence 0.68 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.33 Pain Relevance 0.14
The authors were interested in evaluating the role of VGLUT2 in ventromedial hypothalamic (VMH) neurons, which are predominantly glutamatergic and previously were shown to express VGLUT2 (27).
Gene_expression (express) of VGLUT2 in neurons
15) Confidence 0.68 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.17 Pain Relevance 0
There is also a temporal difference in VGLUT isoform expression, where VGLUT2 is most abundantly expressed during embryonic and early postnatal development, whereafter VGLUT1 becomes the dominating isoform in certain brain areas (11).
Gene_expression (expression) of VGLUT in brain
16) Confidence 0.68 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.05 Pain Relevance 0.38
There is also a temporal difference in VGLUT isoform expression, where VGLUT2 is most abundantly expressed during embryonic and early postnatal development, whereafter VGLUT1 becomes the dominating isoform in certain brain areas (11).
Gene_expression (expressed) of VGLUT2 in brain
17) Confidence 0.68 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.06 Pain Relevance 0.38
However, VGLUT2 is broadly expressed in the brain and spinal cord and is likely to play various roles in many different neuronal circuitries, roles which are now, with the use of gene targeting, becoming increasingly known.
Gene_expression (expressed) of VGLUT2 in brain associated with spinal cord
18) Confidence 0.68 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.14 Pain Relevance 0.15
As the distribution of VGLUT1 and 2 differs between brain regions, the authors performed electrophysiological studies on cells isolated both from the hippocampus (with high VGLUT1 expression) and the thalamus (with high VGLUT2 expression) from wild-type and Vglut2-/- mice respectively.
Gene_expression (expression) of VGLUT2 in thalamus associated with thalamus and hippocampus
19) Confidence 0.68 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.26 Pain Relevance 0.18
Moechars et al. produced a mouse model where VGLUT2-dependent glutamate signalling was inhibited by a complete targeted deletion of the Vglut2 gene (18).
Gene_expression (deletion) of Vglut2 gene associated with glutamate
20) Confidence 0.68 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.48 Pain Relevance 0.05

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