INT139962

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mapk7) cytosol (Mapk7) nucleus (Mapk7)
cell cycle (Mapk7) cytoplasm (Mapk7)
Anatomy Link Frequency
spinal cord 2
bladder 2
Mapk7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 5 96.88 Very High Very High Very High
Inflammation 4 74.76 Quite High
Visceral pain 1 61.60 Quite High
allodynia 1 58.40 Quite High
Hyperalgesia 1 57.84 Quite High
Neuropathic pain 3 50.00 Quite Low
neuralgia 2 10.00 Low Low
Pain 2 10.00 Low Low
Disease Link Frequency Relevance Heat
Cystitis 5 90.52 High High
Overactive Bladder 3 75.00 Quite High
INFLAMMATION 3 74.76 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 61.60 Quite High
Neuropathic Pain 4 58.40 Quite High
Hyperalgesia 1 57.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal injection AS-ODN markedly suppressed the increase of CCI-induced pERK5, pCREB expression in the spinal cord.
Positive_regulation (increase) of Positive_regulation (induced) of pERK5 in spinal cord
1) Confidence 0.41 Published 2009 Journal Neurol. Res. Section Body Doc Link 19426589 Disease Relevance 0 Pain Relevance 0
The level of phospho-ERK1/2 in bladder was increased at 2 and 8 h after CYP injection; the level of phospho-ERK5 in DRG was increased at 8 and 48 h after CYP injection; and the level of phospho-ERK1/2 in lumbar spinal cord was increased at 48 h after CYP injection.
Positive_regulation (increased) of Positive_regulation (increased) of ERK5 in bladder associated with spinal cord
2) Confidence 0.39 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17110531 Disease Relevance 0.72 Pain Relevance 0.45

General Comments

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