INT13997

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Context Info
Confidence 0.36
First Reported 1991
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.31
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENG) cell motility (ENG) cell adhesion (ENG)
nucleolus (ENG) nucleus (ENG) cytoplasm (ENG)
Anatomy Link Frequency
pituitary 2
basal ganglia 2
synovium 2
placentas 2
ENG (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 16 100.00 Very High Very High Very High
Endogenous opioid 14 100.00 Very High Very High Very High
Pain 27 99.42 Very High Very High Very High
Hyperalgesia 33 99.24 Very High Very High Very High
Hippocampus 5 98.56 Very High Very High Very High
Dynorphin 4 98.28 Very High Very High Very High
Somatostatin 3 89.48 High High
Opioid 62 85.68 High High
Inflammation 37 84.24 Quite High
Arthritis 28 83.20 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 6 100.00 Very High Very High Very High
Hypertension 3 100.00 Very High Very High Very High
Pain 27 99.42 Very High Very High Very High
Eclampsia 15 99.30 Very High Very High Very High
Hyperalgesia 75 99.24 Very High Very High Very High
Osteogenic Sarcomas 2 97.64 Very High Very High Very High
Arthritis 29 84.24 Quite High
Stress 38 82.68 Quite High
Hypersensitivity 3 80.44 Quite High
Death 4 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, placental sFlt-1 and sEng production was higher in pre-eclampsia and antihypertensive drugs had no effect on placental production of sFlt-1 and sEng in vitro.
Neg (no) Regulation (effect) of Gene_expression (production) of sEng associated with eclampsia
1) Confidence 0.36 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.48 Pain Relevance 0.05
With the exception of frusemide, none of the antihypertensive drugs tested had any effect on sFlt-1 and sEng production from placental explants of normal pregnancy and women with pre-eclampsia.
Regulation (effect) of Gene_expression (production) of sEng associated with eclampsia
2) Confidence 0.30 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.41 Pain Relevance 0.07
Effects of anti-hypertensive drugs on production of soluble fms-like tyrosine kinase 1 and soluble endoglin from human normal and pre-eclamptic placentas in vitro.
Regulation (Effects) of Gene_expression (production) of soluble endoglin in placentas associated with fibromyalgia and hypertension
3) Confidence 0.16 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 19215236 Disease Relevance 0.50 Pain Relevance 0.08
Expression of CD73 and CD105 (Figure 4c) and CD90 (data not shown, off-scale fluorescence) in cultured synovium-derived cells was not affected by the procedure, as was the expression of CD146 in human osteosarcoma cells (Figure 4d).


Neg (not) Regulation (affected) of Gene_expression (Expression) of CD105 in synovium associated with osteogenic sarcomas
4) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.34 Pain Relevance 0.08
Thus, despite differences in the control END levels in Fig. 4A, B and 4C, the basal PPT (after CFA but before control vector injection) were comparable among these three graphs.
Regulation (control) of Gene_expression (levels) of END
5) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.42 Pain Relevance 0.42
Also, it seems that there was no direct correlation between the control END levels and the extent of hyperalgesia.
Regulation (control) of Gene_expression (levels) of END associated with hyperalgesia
6) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.48 Pain Relevance 0.45
For example, even though the control END levels in Fig. 4A and Fig. 4B were comparable, the END levels after different doses of POMC-MIDGE-NLS varied between the two graphs.
Regulation (control) of Gene_expression (levels) of END
7) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.50 Pain Relevance 0.32
Progesterone did not affect beta-END levels in the frontal and parietal lobes, hippocampus and anterior pituitary, while it caused an increase plasma, hypothalamic and neurointermediate pituitary beta-END levels.
Neg (not) Regulation (affect) of Gene_expression (levels) of beta-END in pituitary associated with hippocampus
8) Confidence 0.01 Published 2006 Journal Neuroendocrinology Section Abstract Doc Link 16931878 Disease Relevance 0 Pain Relevance 0.22
Finally, the GC may influence pain and mood control mainly via effects on enkephalin (ENK) neurons especially in the basal ganglia (mood) and on all beta-endorphin (beta-END) neurons of the arcuate nucleus, while most of the dynorphin neurons are not directly controlled by GC.
Regulation (effects) of Gene_expression (neurons) of beta-END in basal ganglia associated with pain, dynorphin and enkephalin
9) Confidence 0.00 Published 1991 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 1683565 Disease Relevance 0.18 Pain Relevance 0.42
Estrogen regulates hypothalamic gene expression, synthesis and release of the endogenous opioid peptide beta-endorphin (betaEND), although a consensus estrogen response element sequence has not been identified in the rat proopiomelanocortin (POMC) gene.
Regulation (regulates) of Gene_expression (expression) of betaEND associated with endogenous opioid
10) Confidence 0.00 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11124586 Disease Relevance 0 Pain Relevance 0.10
Estrogen regulates hypothalamic gene expression, synthesis and release of the endogenous opioid peptide beta-endorphin (betaEND), although a consensus estrogen response element sequence has not been identified in the rat proopiomelanocortin (POMC) gene.
Regulation (regulates) of Gene_expression (synthesis) of betaEND associated with endogenous opioid
11) Confidence 0.00 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11124586 Disease Relevance 0 Pain Relevance 0.10

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