INT139982

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.33
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BACE2) peptidase activity (BACE2) Golgi apparatus (BACE2)
endoplasmic reticulum (BACE2)
Anatomy Link Frequency
sputum 1
BAE 1
BACE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 18 98.36 Very High Very High Very High
Dismenorea 1 97.04 Very High Very High Very High
Eae 1 96.92 Very High Very High Very High
agonist 3 82.80 Quite High
cINOD 5 81.04 Quite High
Inflammation 2 76.16 Quite High
antagonist 1 74.16 Quite High
noradrenaline 1 62.24 Quite High
Serotonin 1 61.08 Quite High
Neurotransmitter 1 60.36 Quite High
Disease Link Frequency Relevance Heat
Hemorrhage 100 99.36 Very High Very High Very High
Targeted Disruption 2 99.24 Very High Very High Very High
Dysmenorrhea 1 97.04 Very High Very High Very High
Immunization 3 93.88 High High
Premature Birth 14 92.16 High High
Nocardia Infection 22 91.28 High High
Spontaneous Abortion 32 91.12 High High
Mycobacterial Infection 22 90.76 High High
Lung Cancer 8 90.20 High High
Bronchiectasis 18 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a strategy including a routine assessment of the amount of bleeding with a standardized scale, and promoting BAE over surgery, the outcomes of patients were good.
Positive_regulation (promoting) of BAE in BAE associated with hemorrhage
1) Confidence 0.42 Published 2007 Journal Respir Res Section Body Doc Link PMC1802746 Disease Relevance 0.45 Pain Relevance 0
However, targeting beta-secretase is hampered by the lack of suitable inhibitors to date.
Positive_regulation (targeting) of beta-secretase
2) Confidence 0.31 Published 2006 Journal Drugs Section Abstract Doc Link 17112302 Disease Relevance 0.74 Pain Relevance 0.49
Stimulation of the expression or activity of alpha-secretase or neprilysin has been shown to enhance Abeta degradation.
Positive_regulation (Stimulation) of alpha-secretase associated with abeta
3) Confidence 0.31 Published 2006 Journal Drugs Section Abstract Doc Link 17112302 Disease Relevance 0.74 Pain Relevance 0.57
Patients who underwent BAE had a higher respiratory rate, greater amount of bleeding, persistent bloody sputum and/or evidence of active bleeding on fiberoptic bronchoscopy.
Positive_regulation (underwent) of BAE in sputum associated with hemorrhage
4) Confidence 0.28 Published 2007 Journal Respir Res Section Abstract Doc Link PMC1802746 Disease Relevance 0.78 Pain Relevance 0
Other exciting approaches include modulation of A beta processing by inhibiting BACE1 or gamma-secretase or upregulating alpha-secretase; A beta peptide catabolism; inhibition of beta fibrillization; and reducing tau phosphorylation or inhibiting tau aggregation.
Positive_regulation (upregulating) of alpha-secretase associated with eae
5) Confidence 0.02 Published 2008 Journal Bull. Acad. Natl. Med. Section Abstract Doc Link 18819689 Disease Relevance 0.86 Pain Relevance 0.24
This effect is meditated by arachidonic acid, which is released through activation of phospolipase A2 (Bae et al. 1999).
Positive_regulation (activation) of Bae
6) Confidence 0.01 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2367658 Disease Relevance 0.76 Pain Relevance 0.17

General Comments

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