INT139985

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 3.73
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
brain 2
tibia 1
spikes 1
neurons 1
bands 1
Snap25 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 13 96.86 Very High Very High Very High
GABAergic 135 95.44 Very High Very High Very High
Eae 102 91.44 High High
Pain management 1 90.80 High High
tetrodotoxin 3 89.92 High High
neuropeptide release 1 85.28 High High
nociceptor 1 83.20 Quite High
addiction 3 82.64 Quite High
Neurotransmitter 87 81.80 Quite High
Hippocampus 95 80.92 Quite High
Disease Link Frequency Relevance Heat
Aging 1 99.64 Very High Very High Very High
Targeted Disruption 131 98.86 Very High Very High Very High
Embryonic Lethality 17 97.76 Very High Very High Very High
Convulsion 221 97.12 Very High Very High Very High
Cognitive Disorder 119 96.24 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 86 91.44 High High
Pain 2 90.80 High High
Anxiety Disorder 68 88.00 High High
Tremor 34 86.40 High High
Intellectual Impairment 17 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unexpectedly, despite that neo-containing SNAP-25b deficient mutants express only 50% of normal SNAP-25 mRNA levels, protein levels of SNAP-25 are only reduced to 80% of WT littermates.


Negative_regulation (reduced) of SNAP-25
1) Confidence 0.59 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.09 Pain Relevance 0
Together, our results demonstrate that homozygous neo-containing SNAP-25b deficient mouse mutants only express SNAP-25a and that total SNAP-25 mRNA and protein levels are reduced.
Negative_regulation (reduced) of SNAP-25 mRNA
2) Confidence 0.59 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.07 Pain Relevance 0
During higher frequency stimulation (0.5 Hz), when Ca2+ may be expected to be elevated during longer time periods in the stimulated presynaptic terminals, a reduction of the PPF-ratio was observed in neo-containing experiments while there was only a non-significant tendency to a reduction in neo-excised SNAP-25b deficient mice.
Negative_regulation (reduction) of SNAP-25b
3) Confidence 0.59 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0
However, in brains of homozygous neo-containing SNAP-25b deficient mutants SNAP-25 protein levels were reduced by 20%, indicating that the Tkneo gene suppressed gene expression.
Negative_regulation (reduced) of SNAP-25 protein in brains
4) Confidence 0.59 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.17 Pain Relevance 0.03
Our results show, that homozygous neo-containing SNAP-25b deficient mice, lacking SNAP-25b expression and having a moderate reduction in total levels of SNAP-25 protein, exhibit severe developmental and behavioral defects.


Negative_regulation (reduction) of SNAP-25 protein
5) Confidence 0.59 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.15 Pain Relevance 0
Interestingly, the amplitude of spontaneous synchronous calcium spikes in cultures from heterozygous null mutants, expressing reduced levels of SNAP-25, did not differ substantially from wild type neurons.
Negative_regulation (reduced) of SNAP-25 in spikes
6) Confidence 0.59 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.22
Based on results from electrophysiological, behavioral and immunohistochemical experiments we conclude, that under physiological conditions, mice deficient in SNAP-25b have developmental defects, impaired short-term synaptic plasticity, a seizure-prone phenotype and malfunctioning cognitive performance.
Negative_regulation (deficient) of SNAP-25b associated with cognitive disorder and convulsion
7) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.53 Pain Relevance 0.03
The exon 5b was genetically eliminated and replaced with a second supplementary exon 5a, to maintain alternative splicing and normal expression levels, but allowing only SNAP-25a to be expressed.
Negative_regulation (allowing) of SNAP-25a
8) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.66 Pain Relevance 0.04
Reduced SNAP-25 protein levels in absence of SNAP-25b are lethal, as demonstrated in the homozygous neo-containing SNAP-25b deficient mutants.
Negative_regulation (Reduced) of SNAP-25 protein
9) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.18 Pain Relevance 0.04
Targeted disruption of the mouse Snap25 gene has demonstrated that complete removal of SNAP-25 results in total absence of evoked neuroexocytosis and embryonic lethality [27].
Negative_regulation (removal) of SNAP-25 associated with targeted disruption and embryonic lethality
10) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.39 Pain Relevance 0.04
We observed a reduction of PPF in young neo-containing and neo-excised SNAP-25b deficient mutants during low-frequency stimulation (0.2 Hz), suggesting a specific effect of SNAP-25b-deficiency.
Negative_regulation (effect) of SNAP-25b-deficiency
11) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0
Furthermore, neo-excised SNAP-25b deficient mouse mutants demonstrated a clear reduction in PPF at 0.2 Hz (*p <0.05, SNAP-25b KO: n?
Negative_regulation (deficient) of SNAP-25b
12) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0.08
In both the femur and tibia, the hypertrophic zones were significantly reduced in homozygous neo-containing SNAP-25b deficient mutants when compared to WT littermates.
Negative_regulation (reduced) of SNAP-25b in tibia
13) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.22 Pain Relevance 0
Boiling of the samples resulted in the loss of all immunoreactive bands except the monomeric SNAP-25 in both neo-excised SNAP-25b deficient and WT mice.
Negative_regulation (loss) of SNAP-25 in bands
14) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0
Reduced SNAP-25 protein levels in absence of SNAP-25b are lethal, as demonstrated in the homozygous neo-containing SNAP-25b deficient mutants.
Negative_regulation (absence) of SNAP-25b
15) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.18 Pain Relevance 0.04
In the Morris water maze task, homozygous neo-excised SNAP-25b deficient mutants were severely impaired in their ability to acquire the spatial learning task.
Negative_regulation (impaired) of SNAP-25b
16) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.31 Pain Relevance 0.05
Spatial acquisition was examined during five days of training and revealed highly significant differences between the groups with regard to escape latency (p<0.001, Figure 4F), indicating that neo-excised SNAP-25b deficient mice were impaired in their ability to acquire the spatial learning task compared to WT controls.
Negative_regulation (impaired) of SNAP-25b
17) Confidence 0.43 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.05 Pain Relevance 0
Among the brain regions we sampled, the prevalence of SNAP-25a transcripts was remarkably consistent (averaging 9.8% ± 1.7%, S.D.; see Fig. 5B) for neurons selected for either GABAergic or glutamatergic transmitter phenotype.
Negative_regulation (prevalence) of SNAP-25a in brain associated with gabaergic
18) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.22
Fura-2 ratio; n = 7 cultures of each genotype, 5 cells counted per culture, Fig. 2A), indicating that a reduced level of SNAP-25 in Snap25+/- neurons did not affect the calcium currents measured from soma under these conditions.
Negative_regulation (reduced) of SNAP-25 in neurons
19) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.23
In vivo imaging and immunomicroscopy of murine muscles injected with type A toxin revealed that the extended duration of action results from the longevity of its protease, persistence of the cleaved SNAP-25 and a protracted time course for the remodelling of treated nerve-muscle synapses.
Negative_regulation (persistence) of SNAP-25 in synapses associated with aging and imagery
20) Confidence 0.32 Published 2006 Journal Eur. J. Neurol. Section Abstract Doc Link 17112344 Disease Relevance 0.51 Pain Relevance 0.34

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