INT139987

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1, Oprl1) plasma membrane (Oprl1)
Anatomy Link Frequency
amygdala 2
Oprm1 (Rattus norvegicus)
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 3 100.00 Very High Very High Very High
Kappa opioid receptor 3 100.00 Very High Very High Very High
opioid receptor 3 100.00 Very High Very High Very High
nMDA receptor 1 100.00 Very High Very High Very High
Hyperalgesia 2 99.40 Very High Very High Very High
amygdala 6 99.12 Very High Very High Very High
antagonist 4 93.12 High High
tail-flick 7 84.32 Quite High
nMDA receptor antagonist 1 79.92 Quite High
agonist 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that endomorphin-2, but not endomorphin-1, given into the centromedial amygdala stimulates a 3-methoxynaltrexone-sensitive mu-opioid receptor subtype to induce the release of dynorphin A(1-17), which then acts on the NMDA receptor, but not kappa-opioid receptor for producing hyperalgesia.
mu-opioid receptor Positive_regulation (induce) of Localization (release) of kappa-opioid receptor in amygdala associated with hyperalgesia, dynorphin, nmda receptor, kappa opioid receptor, opioid receptor and amygdala
1) Confidence 0.16 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17112504 Disease Relevance 0.17 Pain Relevance 1.35

General Comments

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