INT13999

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Context Info
Confidence 0.67
First Reported 1984
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 4.07
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NEUROD1) nucleus (NEUROD1) transcription factor binding (NEUROD1)
cytoplasm (NEUROD1)
Anatomy Link Frequency
heart 4
PMN 2
NEUROD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 3 99.80 Very High Very High Very High
antiallodynic 1 98.36 Very High Very High Very High
cINOD 2 98.00 Very High Very High Very High
beta blocker 9 97.68 Very High Very High Very High
allodynia 2 95.16 Very High Very High Very High
Angina 2 92.40 High High
antagonist 3 91.76 High High
Neuropathic pain 5 84.60 Quite High
Pain 4 82.28 Quite High
cva 10 75.00 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 6 100.00 Very High Very High Very High
Myocardial Infarction 7 99.78 Very High Very High Very High
Neuropathic Pain 9 99.46 Very High Very High Very High
Stress 6 99.46 Very High Very High Very High
Cv General 3 Under Development 11 92.40 High High
Hypertension 2 92.08 High High
Disease 1 86.76 High High
Pain 4 82.28 Quite High
Coronary Artery Disease 11 82.24 Quite High
Thrombosis 1 81.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased stimulation of beta 1- and beta 2-receptors in the heart increases heart rate and contractility and thereby myocardial oxygen demand.
Positive_regulation (Increased) of Positive_regulation (stimulation) of beta 2 in heart associated with heart rate under development
1) Confidence 0.67 Published 1984 Journal Drugs Section Abstract Doc Link 6151892 Disease Relevance 0.87 Pain Relevance 0.21
In conclusion, these observations suggest that the initial drop in s-Mg and s-K in the early phase of AMI is due to increased stimulation of beta 2-adrenergic receptors; these changes can be prevented partly or completely by the use of nonselective beta-blockers.
Positive_regulation (increased) of Positive_regulation (stimulation) of beta 2 associated with beta blocker and myocardial infarction
2) Confidence 0.67 Published 1993 Journal Angiology Section Abstract Doc Link 8097620 Disease Relevance 0.37 Pain Relevance 0.16
Some forms of stress and epinephrine infusions increase fibrinolysis, probably by stimulating beta 2-adrenoceptors.
Spec (probably) Positive_regulation (increase) of Positive_regulation (stimulating) of beta 2 associated with stress
3) Confidence 0.49 Published 1991 Journal Circulation Section Abstract Doc Link 1683612 Disease Relevance 1.14 Pain Relevance 0.36
Increased stimulation of beta 1- and beta 2-receptors in the heart increases heart rate and contractility and thereby myocardial oxygen demand.
Positive_regulation (increases) of Positive_regulation (stimulation) of beta 2 in heart associated with heart rate under development
4) Confidence 0.49 Published 1984 Journal Drugs Section Abstract Doc Link 6151892 Disease Relevance 0.87 Pain Relevance 0.21
This effect is mediated through the upregulation of beta 2 integrins on the PMN surface.
Positive_regulation (mediated) of Positive_regulation (upregulation) of beta 2 in PMN
5) Confidence 0.49 Published 1997 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 9218092 Disease Relevance 0 Pain Relevance 0.17
Using a murine model of neuropathy, we demonstrated that the stimulation of beta2-adrenergic receptors (beta2-AR) is not only necessary for antidepressant drugs to exert their antiallodynic action but that it is in fact sufficient to alleviate neuropathic allodynia.
Positive_regulation (necessary) of Positive_regulation (stimulation) of beta2 associated with antidepressant, allodynia, neuropathic pain and antiallodynic
6) Confidence 0.49 Published 2009 Journal Recent Pat CNS Drug Discov Section Abstract Doc Link 19538157 Disease Relevance 0.82 Pain Relevance 0.76

General Comments

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