INT140002

Context Info Confidence 0.56 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.65 Pain Relevance 0.32

Anatomy Link Frequency neurite 4 Wld (Mus musculus)

Pain Link Frequency Relevance Heat vincristine 4 98.52 induced neuropathy 2 75.00

Disease Link Frequency Relevance Heat Neurodegenerative Disease 2 94.76 Injury 2 85.76 Wallerian Degeneration 2 83.00 Neuropathic Pain 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The overexpression of WldS delayed the neurite degeneration by vincristine, whereas that of Nmnat1 did not delay it much.

Positive_regulation (overexpression) of Gene_expression (overexpression) of WldS in neurite associated with vincristine

1) Confidence 0.56 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17113230 Disease Relevance 0.33 Pain Relevance 0.16

We generated WldS or Nmnat1-overexpressing Neuro2A cell lines, in which neuronal differentiation including neurite elongation can be induced by retinoic acid.

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of WldS in neurite

2) Confidence 0.41 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17113230 Disease Relevance 0.33 Pain Relevance 0.16

General Comments

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