INT140004

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Srxn1) transport (Accn2) oxidoreductase activity (Srxn1)
plasma membrane (Accn2) DNA binding (Srxn1) cytoplasm (Srxn1)
Anatomy Link Frequency
neurons 1
Srxn1 (Mus musculus)
Accn2 (Mus musculus)
Pain Link Frequency Relevance Heat
PcTx1 3 100.00 Very High Very High Very High
aPETx2 3 93.80 High High
Neuropeptide 1 92.12 High High
cINOD 1 91.36 High High
ASIC 3 87.60 High High
Pain 1 77.80 Quite High
Inflammation 1 75.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 91.12 High High
Anxiety Disorder 1 81.28 Quite High
Pain 1 77.80 Quite High
Targeted Disruption 1 75.60 Quite High
Nociception 1 73.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PcTx1 inhibits ASIC1a homomers with an affinity of 0.7 nM (IC(50)) without any effect on ASIC1a containing heteromers and thus helped to characterize ASIC1a homomeric channels in peripheric and central neurons.
PcTx1 Negative_regulation (inhibits) of ASIC1a in neurons associated with pctx1
1) Confidence 0.01 Published 2007 Journal Toxicon Section Abstract Doc Link 17113616 Disease Relevance 0.47 Pain Relevance 0.83

General Comments

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