INT140011

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.93
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Avp, Dbi) transport (Dbi) mitochondrion (Dbi)
cytoplasm (Dbi) response to stress (Avp) signal transducer activity (Avp)
Avp (Rattus norvegicus)
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 19 100.00 Very High Very High Very High
Raphe magnus 8 99.66 Very High Very High Very High
Central grey 11 98.00 Very High Very High Very High
Dopamine 1 97.70 Very High Very High Very High
Glutamate 1 97.50 Very High Very High Very High
antagonist 7 96.56 Very High Very High Very High
Neurotransmitter 2 95.88 Very High Very High Very High
antinociception 5 94.80 High High
Serotonin 2 93.78 High High
narcan 1 91.16 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 11 98.00 Very High Very High Very High
Pain 1 90.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR data displayed that AVP enhanced proenkephalin and proopiomelanocortin (Pro-beta-Ep) rather than prodynorphin mRNA expressions in culture PAG tissues, and V(2) receptor antagonist weakened proenkephalin and proopiomelanocortin (Pro-beta-Ep), not prodynorphin mRNA expressions in culture PAG tissues, but V(1) receptor antagonist did not influence these mRNA expressions in culture PAG tissues.
AVP Positive_regulation (enhanced) of Pro-beta-Ep associated with antagonist and central grey
1) Confidence 0.07 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113946 Disease Relevance 0.84 Pain Relevance 1.51
The results showed that (1) in the NRM perfuse liquid, pain stimulation could increase the concentrations of AVP, leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek), beta-endorphin (beta-Ep), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), but not change the concentrations of dynorphinA(1-13) (DynA(1-13)), oxytocin, achetylcholine, choline, gamma-aminobutyric acid, glutamate, dopamine, 3,4-dihydroxyphenylacetic acid, homovanilic acid, norepinephrine and epinephrine; (2) in the NRM perfuse liquid, AVP increased the concentrations of L-Ek, M-Ek, beta-Ep, DynA(1-13), 5-HT and 5-HIAA, but did not change the concentrations of oxytocin and the other studied neurotransmitters; (3) AVP antinociception in the NRM was attenuated by cypoheptadine (a 5-HT-receptor antagonist) or naloxone (an opiate receptor antagonist), but was not influenced by the other studied receptor antagonists.
AVP Positive_regulation (increased) of beta-Ep associated with pain, dopamine, narcan, enkephalin, raphe magnus, antinociception, glutamate, neurotransmitter, antagonist, opiate and serotonin
2) Confidence 0.03 Published 2009 Journal Peptides Section Abstract Doc Link 19540433 Disease Relevance 0.09 Pain Relevance 2.10

General Comments

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