INT140030

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.23
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b, Ifng) extracellular region (Il1b, Ifng) aging (Il1b)
Il1b (Mus musculus)
Ifng (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 15 99.78 Very High Very High Very High
cytokine 11 98.54 Very High Very High Very High
Inflammation 7 98.36 Very High Very High Very High
Glutamate 4 95.52 Very High Very High Very High
substance P 5 92.68 High High
intrathecal 1 90.08 High High
Intracerebroventricular 2 87.04 High High
Antinociceptive 2 82.92 Quite High
nociceptor 2 25.00 Low Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 4 99.80 Very High Very High Very High
Pain 10 99.78 Very High Very High Very High
Stress 8 99.40 Very High Very High Very High
INFLAMMATION 7 98.36 Very High Very High Very High
Necrosis 1 92.32 High High
Cancer 1 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the pro-inflammatory cytokine pain model, a single immobilization stress decreased the pain behaviors induced by TNF-alpha, IL-1beta administered i.t. but not by IFN-gamma administered i.t.
IL-1beta Neg (not) Positive_regulation (induced) of Neg (not) Gene_expression (administered) of IFN-gamma associated with stress, pain, inflammation and cytokine
1) Confidence 0.48 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113957 Disease Relevance 1.69 Pain Relevance 1.50
The ginsenosides, Rb1, Rb2, Rc, Rd, Re, Rf and Rg1, significantly attenuated the nociceptive behavior induced by TNF-alpha, IL-1 beta, and IFN-gamma injection, but ginsenoside-Rg3 did not.
IL-1 beta Positive_regulation (induced) of Gene_expression (injection) of IFN-gamma associated with nociception
2) Confidence 0.13 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 18409051 Disease Relevance 0.54 Pain Relevance 0.50

General Comments

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