INT140036

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.00
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 8
neuronal 2
hippocampus 2
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 7 100.00 Very High Very High Very High
Chronic pancreatitis 5 99.84 Very High Very High Very High
fluoxetine 9 99.72 Very High Very High Very High
Bile 3 99.12 Very High Very High Very High
alcohol 1 98.52 Very High Very High Very High
Serotonin 3 86.84 High High
antidepressant 3 85.48 High High
Pain 1 82.40 Quite High
Inflammation 1 79.16 Quite High
Neurobehavioral 1 20.04 Low Low
Disease Link Frequency Relevance Heat
Pancreatitis 5 99.84 Very High Very High Very High
Recurrence 2 98.88 Very High Very High Very High
Neurodegenerative Disease 8 98.08 Very High Very High Very High
Stress Incontinence 2 94.48 High High
Manic Depressive Disorder 1 90.56 High High
Fibrosis 2 90.08 High High
Injury 10 83.44 Quite High
Pain 1 82.40 Quite High
INFLAMMATION 1 79.16 Quite High
Stress 9 77.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of Notch1 in rat cortical neurons results in an increase in neuronal branching and an antagonism of neurite extension [100].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Notch1 in neuronal
1) Confidence 0.61 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0
Simultaneously, hippocampal neurogenesis was determined by assessing cell proliferation, survival and differentiation. mRNA and protein expression of Notch1 signaling components (including Jag1, NICD, Hes1 and Hes5) in the hippocampus increased after fluoxetine administration, accompanied by cell proliferation and survival.
Positive_regulation (increased) of Gene_expression (expression) of Notch1 in hippocampus associated with hippocampus, neurodegenerative disease and fluoxetine
2) Confidence 0.47 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801843 Disease Relevance 0.41 Pain Relevance 0.90
Wnt signaling activates usually the expression of Notch ligands.
Positive_regulation (activates) of Gene_expression (expression) of Notch in Notch
3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.10 Pain Relevance 0
Notch-2, -3, and -4 mRNA, were overexpressed in chronic pancreatitis specimens.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Notch in Notch associated with chronic pancreatitis
4) Confidence 0.22 Published 2006 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17114010 Disease Relevance 0.74 Pain Relevance 0.68
The pharmacological effects are mediated by the activation of Notch signaling in the NSC, but not by the inhibition of GSK-3b signaling or inositol depletion, currently popular models to explain mood stabilizers' action.
Neg (not) Positive_regulation (activation) of Gene_expression (signaling) of Notch in Notch
5) Confidence 0.17 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 19108505 Disease Relevance 0.58 Pain Relevance 0.28
Indeed irradiation activated the Notch pathway, as demonstrated by the expression of the Notch target genes Hey1, and its inhibition by the ?
Positive_regulation (demonstrated) of Gene_expression (expression) of Notch in Notch
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.18 Pain Relevance 0

General Comments

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