INT140037

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.34
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 6
mesothelial cell 2
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 5 99.98 Very High Very High Very High
Inflammation 3 98.12 Very High Very High Very High
Pain 1 94.56 High High
alcohol 1 78.56 Quite High
Bile 3 77.84 Quite High
Eae 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 5 99.98 Very High Very High Very High
Infection 16 99.90 Very High Very High Very High
Mesothelioma 110 98.92 Very High Very High Very High
INFLAMMATION 3 98.12 Very High Very High Very High
Pain 1 94.56 High High
Injury 4 93.60 High High
Fibrosis 1 87.20 High High
Metastasis 4 69.36 Quite High
Genetic Predisposition To Disease 4 52.92 Quite High
Malignant Neoplastic Disease 21 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, low levels of cholesterol leads to high expression of Adam10, coding for a protease also known as Kuzbanian, which is essential for Notch activation [55].
Positive_regulation (essential) of Positive_regulation (activation) of Notch in Notch
1) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0 Pain Relevance 0
Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway.
Positive_regulation (requires) of Positive_regulation (activation) of notch in notch associated with chronic pancreatitis
2) Confidence 0.21 Published 2006 Journal J. Gastrointest. Surg. Section Title Doc Link 17114010 Disease Relevance 0.79 Pain Relevance 0.69
For example, Siah1, which belongs to the E3 ubiquitin ligase complex, is known to promote degradation of Numb, and thereby leads to activation of Notch [68]–[71].
Positive_regulation (leads) of Positive_regulation (activation) of Notch in Notch
3) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0 Pain Relevance 0
Another possible role of SV40 in MPM that was not stated above is that SV40 infection may increase the transcription and activation of Notch-1, which may have an important role in mesothelial cell transformation and proliferation [121].
Spec (may) Positive_regulation (increase) of Positive_regulation (activation) of Notch-1 in mesothelial cell associated with mesothelioma and infection
4) Confidence 0.02 Published 2008 Journal J Carcinog Section Body Doc Link PMC2507706 Disease Relevance 0.55 Pain Relevance 0

General Comments

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