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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mapk7) cytosol (Mapk7) nucleus (Mapk7)
cell cycle (Mapk7) kinase activity (Mapk7) cytoplasm (Mapk7)
Mapk7 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 1 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1 96.48 Very High Very High Very High
Death 1 95.94 Very High Very High Very High
Lymphatic System Cancer 1 94.32 High High
Cancer 1 86.24 High High
Stress 1 81.92 Quite High
Malignant Neoplastic Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we show that reducing ERK5 levels with a specific small hairpin RNA 5 (shERK5) reduced cell viability, sensitized cells to death receptor-induced apoptosis, and blocked the palliative effects of phorbol ester in anti-Fas Ab-treated cells. shERK5 decreased nuclear accumulation of the NF-kappaB p65 subunit, and conversely, ectopic activation of ERK5 led to constitutive nuclear localization of p65 and increased its ability to trans activate specific reporter genes.
Positive_regulation (increased) of Positive_regulation (activation) of ERK5 associated with apoptosis, death and palliative
1) Confidence 0.45 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114430 Disease Relevance 0.45 Pain Relevance 0.10

General Comments

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