INT140045

Context Info Confidence 0.45 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.45 Pain Relevance 0.10

cell differentiation (Mapk7) cytosol (Mapk7) nucleus (Mapk7) cell cycle (Mapk7) kinase activity (Mapk7) cytoplasm (Mapk7)

Mapk7 (Mus musculus)

Pain Link Frequency Relevance Heat palliative 1 97.04

Disease Link Frequency Relevance Heat Apoptosis 1 96.48 Death 1 95.94 Lymphatic System Cancer 1 94.32 Cancer 1 86.24 Stress 1 81.92 Malignant Neoplastic Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this study, we show that reducing ERK5 levels with a specific small hairpin RNA 5 (shERK5) reduced cell viability, sensitized cells to death receptor-induced apoptosis, and blocked the palliative effects of phorbol ester in anti-Fas Ab-treated cells. shERK5 decreased nuclear accumulation of the NF-kappaB p65 subunit, and conversely, ectopic activation of ERK5 led to constitutive nuclear localization of p65 and increased its ability to trans activate specific reporter genes.

Positive_regulation (increased) of Positive_regulation (activation) of ERK5 associated with apoptosis, death and palliative

1) Confidence 0.45 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114430 Disease Relevance 0.45 Pain Relevance 0.10

General Comments

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