INT140052

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 1.63
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cish)
Anatomy Link Frequency
vesicle 2
adult brain 1
nucleus 1
Cish (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 202 97.32 Very High Very High Very High
Inflammation 145 88.40 High High
addiction 7 88.08 High High
long-term potentiation 10 78.96 Quite High
Inflammatory response 1 76.40 Quite High
imagery 2 69.32 Quite High
Glutamate 3 69.04 Quite High
COX-2 inhibitor 1 64.40 Quite High
cINOD 5 63.16 Quite High
adenocard 2 62.64 Quite High
Disease Link Frequency Relevance Heat
Necrosis 10 98.82 Very High Very High Very High
Cancer 58 98.64 Very High Very High Very High
Repression 5 94.20 High High
Sprains And Strains 63 92.00 High High
INFLAMMATION 134 88.40 High High
Disease 168 87.88 High High
Pathologic Processes 5 73.72 Quite High
Targeted Disruption 84 69.00 Quite High
Non-genital Cutaneous Warts 5 60.40 Quite High
Sepsis 5 60.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CIS and SOCS2 bind to phosphorylated tyrosine residues on activated (phosphorylated) cytokine receptors.
CIS Binding (bind) of associated with cytokine
1) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.14 Pain Relevance 0.24
This domain is also present in spermadhesins, tumour necrosis factor-stimulated gene-6 and the complement proteins C1r, C1s and mannan-binding lectin-associated serine proteinases, among others [21], and there is evidence to suggest that these domains mediate protein-protein interactions with other CUB domain-containing proteins [22,23].


C1s Binding (binding) of associated with necrosis and cancer
2) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.20 Pain Relevance 0.03
As mentioned below, receptor-CIS/SOCS complex is degraded by the ubiquitin–proteasome system, which could be an important inhibitory mechanism.
SOCS Binding (complex) of
3) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0 Pain Relevance 0.15
As mentioned below, receptor-CIS/SOCS complex is degraded by the ubiquitin–proteasome system, which could be an important inhibitory mechanism.
CIS Binding (complex) of
4) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0 Pain Relevance 0.15
The importance of the SOCS box has been recognized from the following evidence: the SOCS box of SOCS1 is necessary for the suppression of the oncogenic activity of TEL-JAK2 by SOCS1 [27,28] as well as for the degradation of wild-type activated JAK2 [29], and mice that were genetically modified to lack only the SOCS box of SOCS1 exhibited inflammatory diseases similar to complete SOCS1-deficient mice with slower onsets [30].
SOCS Binding (recognized) of associated with inflammation and disease
5) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.24 Pain Relevance 0.04
For this reason we closely examined this variant to understand the mechanisms that generate the strong cis eQTL.


cis Spec (examined) Binding (generate) of
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.38 Pain Relevance 0.03
Using electrophoretic mobility supershift and chromatin immunoprecipitation assays, we cataloged binding to each functional cis element and found them occupied to varying extents and by different transcription factors during the 12 h following LPS treatment.
cis Binding (binding) of
7) Confidence 0.11 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114486 Disease Relevance 0.56 Pain Relevance 0.24
However, they found that cis-interactions of the EC 4–5 regions may also occur and that desmosomal cadherins rather show periodically zipper-like arrangements similar to classical cadherins (Boggon et al. 2002).


cis Binding (interactions) of
8) Confidence 0.07 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.05 Pain Relevance 0.03
Cis-configuration is favorable for binding to the receptor.
Cis Binding (binding) of
9) Confidence 0.06 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC3023065 Disease Relevance 0 Pain Relevance 0.06
Thus, although the four Egr family members encode closely related Cys2–Hys2 zinc-finger transcription factors, highly homologous (92%) in the zinc-finger DNA binding domain (Beckmann and Wilce, 1997) and interacting with the same GC-rich consensus DNA motif, suggesting that the proteins may bind to cis-regulatory regions of at least a subset of the same target genes (Chavrier et al., 1990; Lemaire et al., 1990; Swirnoff and Milbrandt, 1995), comparison of the phenotypes of Egr1 and Egr3 mutant mice raises the possibility that Egr members may have at least in part diverging physiological functions in the adult brain.
cis-regulatory Binding (bind) of in adult brain
10) Confidence 0.05 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.06 Pain Relevance 0.08
Alternatively, the T254I mutation could stabilize the cis SNARE complex such that it impedes vesicle recycling and ultimately reduces exocytosis upon repetitive nerve stimulation.


cis Binding (complex) of in vesicle
11) Confidence 0.02 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0 Pain Relevance 0.04
As vesicles undergo fusion, the SNARE complex rearranges from a trans to a cis configuration such that all the SNARE proteins are localized to one membrane.
cis Binding (configuration) of in vesicles
12) Confidence 0.02 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0 Pain Relevance 0
They are activated by ligand binding; form heterodimers, usually with the retinoid X receptor (RXR); translocate to the nucleus; bind to a cis-acting XRE consisting of a direct repeat of two hexanucleotides, separated by one or two nucleotides, in the promoter region of the target gene; and enhance target gene expression [17].
cis-acting Binding (bind) of in nucleus
13) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0 Pain Relevance 0

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