INT140053

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.40
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cish)
Anatomy Link Frequency
immune cells 2
proximal 1
cleavage 1
vesicle 1
Cish (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 188 99.98 Very High Very High Very High
tolerance 18 98.80 Very High Very High Very High
Action potential 10 93.40 High High
Dopamine 15 92.52 High High
Catechol-O-methyltransferase 27 88.56 High High
Inflammation 149 77.44 Quite High
COX-2 inhibitor 1 69.44 Quite High
cINOD 6 68.20 Quite High
Inflammatory response 18 66.08 Quite High
chemokine 2 45.12 Quite Low
Disease Link Frequency Relevance Heat
Repression 1 99.62 Very High Very High Very High
Disease 70 99.16 Very High Very High Very High
Cognitive Disorder 6 98.80 Very High Very High Very High
Sprains And Strains 72 91.28 High High
Stomach Disease 2 84.92 Quite High
Malignant Neoplastic Disease 1 84.24 Quite High
Infection 57 79.68 Quite High
INFLAMMATION 163 77.44 Quite High
Targeted Disruption 35 73.84 Quite High
Stomach Cancer 4 71.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SOCS and cytokine-inducible SH2 protein (CIS) are a family of intracellular proteins, several of which have been shown to regulate the responses of immune cells to cytokines [6-10].
Positive_regulation (inducible) of SH2 protein in immune cells associated with cytokine
1) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.14 Pain Relevance 0.52
SOCS and cytokine-inducible SH2 protein (CIS) are a family of intracellular proteins, several of which have been shown to regulate the responses of immune cells to cytokines [6-10].
Positive_regulation (inducible) of CIS in immune cells associated with cytokine
2) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.14 Pain Relevance 0.52
CIS is induced by cytokines that activate STAT5 and bind to receptors that activate STAT5, namely erythropoietin, IL-2, IL-3, prolactin and growth hormone (GH) [11].
Positive_regulation (induced) of CIS associated with cytokine
3) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.12 Pain Relevance 0.17
Variation in Comt mRNA expression and cis-regulation in CNS and peripheral tissues
Positive_regulation (Variation) of cis
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.80 Pain Relevance 0.09
The E-box mediates transcriptional repression whereas the other cis-elements are activating.
Positive_regulation (activating) of cis associated with repression
5) Confidence 0.15 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114486 Disease Relevance 0.58 Pain Relevance 0.24
Relevant to the phenomenon of tolerance, Dennis et al. reported that recognition of B. burgdorferi activates SOCS [95] and Diterich et al. showed that B. burgdorferi can tolerize M?
Positive_regulation (activates) of SOCS associated with tolerance
6) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0.38
Ile60 were the essential region required for both cis and trans activity of the NS3 protease which has been demonstrated by cis- and trans-cleavage assays of the deletions at the N-terminal of NS2B [7].
Positive_regulation (required) of cis in cleavage
7) Confidence 0.08 Published 2008 Journal Bioinformation Section Body Doc Link PMC2586131 Disease Relevance 0 Pain Relevance 0
Another possibility predicted by our structural modeling is that the T254I mutation may slow vesicle recycling by stabilizing post-fusion cis SNARE complexes.
Positive_regulation (stabilizing) of cis in vesicle
8) Confidence 0.02 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0 Pain Relevance 0.07
We have previously demonstrated that H. pylori can directly influence expression of Cox-2 in gastric epithelial cells through transcriptional mechanisms, and identified MAPK-ERK-dependent activation of a proximal cis-regulatory CRE-Ebox element as a key step in the H. pylori-response of the Cox-2 gene [22].
Positive_regulation (activation) of cis-regulatory in proximal
9) Confidence 0.01 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.62 Pain Relevance 0

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