INT140054

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.90
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk9) mitochondrion (Mapk9) nucleus (Mapk9)
kinase activity (Mapk9) transcription factor binding (Mapk9) cytoplasm (Mapk9)
Anatomy Link Frequency
liver 1
frontal cortex 1
Mapk9 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 3 99.68 Very High Very High Very High
Paracetamol 5 99.50 Very High Very High Very High
Inflammatory response 1 98.16 Very High Very High Very High
fluoxetine 2 94.44 High High
depression 4 88.48 High High
Inflammation 4 75.00 Quite High
antidepressant 2 66.48 Quite High
COX-2 inhibitor 1 48.72 Quite Low
cINOD 1 47.48 Quite Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 3 99.92 Very High Very High Very High
Stress 9 99.90 Very High Very High Very High
Overdose 1 98.64 Very High Very High Very High
Urological Neuroanatomy 3 98.52 Very High Very High Very High
Apoptosis 2 98.46 Very High Very High Very High
INFLAMMATION 5 97.80 Very High Very High Very High
Liver Failure 1 96.56 Very High Very High Very High
Depression 4 88.48 High High
Repression 1 78.52 Quite High
Sepsis 1 44.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
Negative_regulation (inhibiting) of c-Jun N-terminal kinase in liver associated with paracetamol, injury and apoptosis
1) Confidence 0.25 Published 2008 Journal Gastroenterology Section Title Doc Link 18700144 Disease Relevance 0.58 Pain Relevance 0.47
In support of this concept, we found, using inhibitors of Jun kinase and NF-kappaB p50 nuclear localization, that COX-2 gene transcription was completely dependent on phospho-c-Jun plus p50 at 6 h after LPS treatment but was only partially dependent on the combination of these factors at later treatment times.
Negative_regulation (inhibitors) of Jun kinase
2) Confidence 0.20 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114486 Disease Relevance 0.31 Pain Relevance 0.11
Western blot study revealed that rats subjected to prenatal stress had decreased levels of p-JNK1 and p-JNK2 in the hippocampus and p-p38 in the frontal cortex, but the concentrations of p-ERK1 and p-ERK2 were not changed.
Negative_regulation (decreased) of p-JNK2 in frontal cortex associated with stress, urological neuroanatomy and hippocampus
3) Confidence 0.00 Published 2010 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20436222 Disease Relevance 1.02 Pain Relevance 0.47

General Comments

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