INT140058

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 8.69
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cish)
Anatomy Link Frequency
proximal 1
Cish (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 261 99.84 Very High Very High Very High
Opioid 25 99.22 Very High Very High Very High
Inflammatory response 27 96.96 Very High Very High Very High
Catechol-O-methyltransferase 71 96.20 Very High Very High Very High
Glutamate receptor 11 95.96 Very High Very High Very High
Inflammation 170 95.52 Very High Very High Very High
Dopamine 34 91.00 High High
Neurotransmitter 16 78.60 Quite High
Central nervous system 1 76.16 Quite High
rheumatoid arthritis 30 74.72 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 464 98.96 Very High Very High Very High
Disease 142 97.64 Very High Very High Very High
Cognitive Disorder 18 97.28 Very High Very High Very High
INFLAMMATION 191 96.96 Very High Very High Very High
Hyperlipidemia 3 95.56 Very High Very High Very High
Targeted Disruption 48 95.36 Very High Very High Very High
Mycobacterial Infection 115 94.36 High High
Diabetes Mellitus 6 91.84 High High
Obesity 11 91.48 High High
Pressure And Volume Under Development 8 90.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A Drosophila SOCS protein that is highly homologous to mammalian SOCS5 was cloned and named SOCS36E.
Regulation (named) of SOCS
1) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.46 Pain Relevance 0
Although there was no evidence for cis-eQTLs for the 12 other DE Lore genes in the B6 and D2 mouse strains, this did not exclude the possibility that these genes are regulated in cis in the ILS and ISS mouse strains.
Regulation (regulated) of cis associated with sprains and strains
2) Confidence 0.22 Published 2006 Journal Mamm Genome Section Body Doc Link PMC2677977 Disease Relevance 0.42 Pain Relevance 0
SOCS proteins are regulators of cytokine signal transduction and are essential to normal immune physiology, but they also seem to contribute to the development of immunological disorders including inflammatory diseases.
Regulation (regulators) of SOCS associated with inflammation, disease and cytokine
3) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.81 Pain Relevance 0.25
These studies are encouraging for controlling cytokine-related pathological conditions by mimicking or modulating SOCS proteins.


Regulation (modulating) of SOCS associated with cytokine
4) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.78 Pain Relevance 0.24
The cause of this Comt cis-regulation is the insertion of a strong and premature polyadenylation signal in the proximal 3?
Regulation (regulation) of cis in proximal
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.86 Pain Relevance 0.12
Variation in Comt mRNA expression and cis-regulation in CNS and peripheral tissues
Regulation (regulation) of cis
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.74 Pain Relevance 0.09
Differentially expressed genes were also analyzed to identify their expression QTLs (eQTLs) to determine if any DE genes are likely to be cis-regulated, thus bolstering the case for functional effects of these promoter region SNPs.
Regulation (regulated) of cis
7) Confidence 0.10 Published 2006 Journal Mamm Genome Section Body Doc Link PMC2677977 Disease Relevance 0.31 Pain Relevance 0
There is no evidence from the WebQTL database to suggest that the remaining Lore DE genes are cis-regulated, although that cannot be ruled out.
Regulation (regulated) of cis
8) Confidence 0.10 Published 2006 Journal Mamm Genome Section Body Doc Link PMC2677977 Disease Relevance 0.51 Pain Relevance 0
Sequencing promoter regions of DE Lore genes with evidence of cis-regulation
Regulation (regulation) of cis
9) Confidence 0.10 Published 2006 Journal Mamm Genome Section Body Doc Link PMC2677977 Disease Relevance 0.41 Pain Relevance 0
The differential expression of three genes, Slc22a4, Pcsk2, and the clone BG075643, had significant linkage scores associated with markers near to their genomic locations and thus are potentially cis-regulated.
Regulation (regulated) of cis
10) Confidence 0.10 Published 2006 Journal Mamm Genome Section Body Doc Link PMC2677977 Disease Relevance 0.49 Pain Relevance 0
The only peak reaching significance is on Chr 11 near the Slc22a4 gene, thus implying cis-regulation of this transcript.


Regulation (regulation) of cis
11) Confidence 0.10 Published 2006 Journal Mamm Genome Section Body Doc Link PMC2677977 Disease Relevance 0.47 Pain Relevance 0
This suggests that the cis elements and their cognate transcription factors participate in a sequential, coordinated regulation of COX-2 gene expression during an inflammatory response.
Regulation (participate) of cis associated with inflammatory response
12) Confidence 0.09 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114486 Disease Relevance 0.48 Pain Relevance 0.23
In turn, SOCS activity is modulated via the PI3K/AKT/p38-MAPK pathway.
Regulation (modulated) of SOCS
13) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.56 Pain Relevance 0.24
p38-STAT1-IRF1 signaling positively regulates socs activity [26],[30] and negatively regulates tlr2 activity [37].
Regulation (ely regul) of socs
14) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0.03
Cis-acting regulation of expression results from DNA variations of a gene that directly influence mRNA level of that gene [53].
Regulation (regulation) of Cis-acting
15) Confidence 0.06 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.22 Pain Relevance 0.16
-adrenergic) and hormonal receptors (e.g. glucocorticoids, ACTH, opioid), whose transmembrane signaling could alter FoxP3, and SOCS and the associated signaling network.
Regulation (alter) of SOCS associated with opioid
16) Confidence 0.04 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.52 Pain Relevance 0.18
On the other hand, TDM which lacks both cis- and trans-cyclopropanation, as do those isolated from the ?
Regulation (lacks) of cis
17) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.25 Pain Relevance 0
Somatic instability of trinucleotide repeats not only requires trans-acting factors, but has also been shown to depend on cis-acting sequences [10].
Regulation (depend) of cis-acting
18) Confidence 0.03 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0.39 Pain Relevance 0.04

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