INT140070

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.65
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cell 2
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 34 96.36 Very High Very High Very High
Kinase C 24 92.44 High High
abdominal pain 1 82.08 Quite High
Multiple sclerosis 121 63.08 Quite High
Opioid 6 35.84 Quite Low
transdermal 2 35.04 Quite Low
rheumatoid arthritis 17 12.80 Low Low
Inflammation 45 5.00 Very Low Very Low Very Low
Central nervous system 28 5.00 Very Low Very Low Very Low
cytokine 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 451 96.72 Very High Very High Very High
Frailty 9 96.08 Very High Very High Very High
Cognitive Disorder 10 93.80 High High
Malabsorption Syndromes 3 92.36 High High
Hypocalcemia 2 88.68 High High
Thyroid Disease 3 87.76 High High
Osteoporosis 1 84.48 Quite High
Anaemia 1 83.88 Quite High
Weight Loss 1 83.12 Quite High
Diarrhoea 1 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, testosterone treatment was also shown to favourably affect the immune system by inducing decreasing CD4+ T cell percentage and increasing natural killer (NK) cells.
Positive_regulation (inducing) of Negative_regulation (decreasing) of CD4 in T cell
1) Confidence 0.30 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.59 Pain Relevance 0.12
PMA induced a significant decrease in CD4 levels over a period of 6 hours (Fig. 4A).
Positive_regulation (induced) of Negative_regulation (decrease) of CD4
2) Confidence 0.27 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.06 Pain Relevance 0
Several studies have shown that PMA treatment mimics the mechanism of antigen induced CD4 downregulation [23,60].
Positive_regulation (induced) of Negative_regulation (downregulation) of CD4
3) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.49 Pain Relevance 0.18
Our findings indicate that SDF-1-induced CXCR4 downregulation is defective when ESCRT-I function is impaired, while PMA-induced CD4 downregulation is not.
Positive_regulation (induced) of Negative_regulation (downregulation) of CD4
4) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.41 Pain Relevance 0
In the present study, we show that PMA-induced CD4 downregulation can occur efficiently in the absence of functional ESCRT-I and Vps4 (Fig. 4) and that expression of HIV-1 Gag has no effect on this process (Fig. 5).
Positive_regulation (induced) of Negative_regulation (downregulation) of CD4 associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.61 Pain Relevance 0.16
In order to determine whether the AAA-type ATPase Vps4 plays a role in PMA-induced CD4 downregulation, a dominant negative form of Vps4 (Vps4E228Q-GFP) was co-expressed with CD4.
Spec (whether) Positive_regulation (induced) of Spec (whether) Negative_regulation (downregulation) of CD4
6) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0 Pain Relevance 0
SDF-1-induced CXCR4 downregulation was sharply reduced when TSG101 function is inhibited, while PMA-induced CD4 downregulation was relatively unaffected.
Positive_regulation (induced) of Negative_regulation (downregulation) of CD4
7) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.42 Pain Relevance 0
Following gluten-free diet a normalization of clinical and serological findings was observed, bone mass density improved and a reduction of L-T4, calcium and vitamin D requirements was observed.
Positive_regulation (requirements) of Negative_regulation (reduction) of L-T4
8) Confidence 0.24 Published 2006 Journal J. Endocrinol. Invest. Section Abstract Doc Link 17114916 Disease Relevance 1.08 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox