INT140070

Context Info Confidence 0.30 First Reported 2006 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 7 Total Number 8 Disease Relevance 3.65 Pain Relevance 0.54

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)

Anatomy Link Frequency T cell 2 Cd4 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 34 96.36 Kinase C 24 92.44 abdominal pain 1 82.08 Multiple sclerosis 121 63.08 Opioid 6 35.84 transdermal 2 35.04 rheumatoid arthritis 17 12.80 Inflammation 45 5.00 Central nervous system 28 5.00 cytokine 23 5.00

Disease Link Frequency Relevance Heat Acquired Immune Deficiency Syndrome Or Hiv Infection 451 96.72 Frailty 9 96.08 Cognitive Disorder 10 93.80 Malabsorption Syndromes 3 92.36 Hypocalcemia 2 88.68 Thyroid Disease 3 87.76 Osteoporosis 1 84.48 Anaemia 1 83.88 Weight Loss 1 83.12 Diarrhoea 1 82.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finally, testosterone treatment was also shown to favourably affect the immune system by inducing decreasing CD4+ T cell percentage and increasing natural killer (NK) cells.

Positive_regulation (inducing) of Negative_regulation (decreasing) of CD4 in T cell

1) Confidence 0.30 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.59 Pain Relevance 0.12

PMA induced a significant decrease in CD4 levels over a period of 6 hours (Fig. 4A).

Positive_regulation (induced) of Negative_regulation (decrease) of CD4

2) Confidence 0.27 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.06 Pain Relevance 0

Several studies have shown that PMA treatment mimics the mechanism of antigen induced CD4 downregulation [23,60].

Positive_regulation (induced) of Negative_regulation (downregulation) of CD4

3) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.49 Pain Relevance 0.18

Our findings indicate that SDF-1-induced CXCR4 downregulation is defective when ESCRT-I function is impaired, while PMA-induced CD4 downregulation is not.

Positive_regulation (induced) of Negative_regulation (downregulation) of CD4

4) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.41 Pain Relevance 0

In the present study, we show that PMA-induced CD4 downregulation can occur efficiently in the absence of functional ESCRT-I and Vps4 (Fig. 4) and that expression of HIV-1 Gag has no effect on this process (Fig. 5).

Positive_regulation (induced) of Negative_regulation (downregulation) of CD4 associated with acquired immune deficiency syndrome or hiv infection

5) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.61 Pain Relevance 0.16

In order to determine whether the AAA-type ATPase Vps4 plays a role in PMA-induced CD4 downregulation, a dominant negative form of Vps4 (Vps4E228Q-GFP) was co-expressed with CD4.

Spec (whether) Positive_regulation (induced) of Spec (whether) Negative_regulation (downregulation) of CD4

6) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0 Pain Relevance 0

SDF-1-induced CXCR4 downregulation was sharply reduced when TSG101 function is inhibited, while PMA-induced CD4 downregulation was relatively unaffected.

Positive_regulation (induced) of Negative_regulation (downregulation) of CD4

7) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.42 Pain Relevance 0

Following gluten-free diet a normalization of clinical and serological findings was observed, bone mass density improved and a reduction of L-T4, calcium and vitamin D requirements was observed.

Positive_regulation (requirements) of Negative_regulation (reduction) of L-T4

8) Confidence 0.24 Published 2006 Journal J. Endocrinol. Invest. Section Abstract Doc Link 17114916 Disease Relevance 1.08 Pain Relevance 0.08

General Comments

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