INT140070
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Finally, testosterone treatment was also shown to favourably affect the immune system by inducing decreasing CD4+ T cell percentage and increasing natural killer (NK) cells. | |||||||||||||||
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PMA induced a significant decrease in CD4 levels over a period of 6 hours (Fig. 4A). | |||||||||||||||
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Several studies have shown that PMA treatment mimics the mechanism of antigen induced CD4 downregulation [23,60]. | |||||||||||||||
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Our findings indicate that SDF-1-induced CXCR4 downregulation is defective when ESCRT-I function is impaired, while PMA-induced CD4 downregulation is not. | |||||||||||||||
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In the present study, we show that PMA-induced CD4 downregulation can occur efficiently in the absence of functional ESCRT-I and Vps4 (Fig. 4) and that expression of HIV-1 Gag has no effect on this process (Fig. 5). | |||||||||||||||
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In order to determine whether the AAA-type ATPase Vps4 plays a role in PMA-induced CD4 downregulation, a dominant negative form of Vps4 (Vps4E228Q-GFP) was co-expressed with CD4. | |||||||||||||||
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SDF-1-induced CXCR4 downregulation was sharply reduced when TSG101 function is inhibited, while PMA-induced CD4 downregulation was relatively unaffected. | |||||||||||||||
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Following gluten-free diet a normalization of clinical and serological findings was observed, bone mass density improved and a reduction of L-T4, calcium and vitamin D requirements was observed. | |||||||||||||||
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