INT140071

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.90
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
corneas 2
lung 2
T cell 2
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 47 84.08 Quite High
abdominal pain 1 82.08 Quite High
cytokine 71 80.88 Quite High
Potency 2 66.48 Quite High
Inflammatory response 3 58.04 Quite High
agonist 11 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 54 99.84 Very High Very High Very High
Infection 104 99.60 Very High Very High Very High
Eye Disease 2 98.68 Very High Very High Very High
Lymphadenopathy 1 96.48 Very High Very High Very High
Hepatitis C Virus Infection 102 96.44 Very High Very High Very High
Splenomegaly 1 94.88 High High
Systemic Lupus Erythematosus 119 93.24 High High
Malabsorption Syndromes 3 92.36 High High
Disease 67 89.84 High High
Hypocalcemia 2 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with pBTLA reduces CD4+ T cell response to HSV-1 infection in corneas
Negative_regulation (reduces) of Positive_regulation (response) of CD4 in corneas associated with cold sores and infection
1) Confidence 0.39 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.16 Pain Relevance 0.14
Interestingly, the three subjects who exhibited F protein specific CD4+ T cell response were all anti-F antibody positive by the ELISA assays.
Negative_regulation (exhibited) of Positive_regulation (response) of CD4 in T cell
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 0.50 Pain Relevance 0.03
Clodronate treatment resulted in greater numbers of activated CD8 and CD4 T cells in the MA15-infected lung (Fig.
Negative_regulation (numbers) of Positive_regulation (activated) of CD4 in lung
3) Confidence 0.29 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.21 Pain Relevance 0
Following gluten-free diet a normalization of clinical and serological findings was observed, bone mass density improved and a reduction of L-T4, calcium and vitamin D requirements was observed.
Negative_regulation (reduction) of Positive_regulation (requirements) of L-T4
4) Confidence 0.22 Published 2006 Journal J. Endocrinol. Invest. Section Abstract Doc Link 17114916 Disease Relevance 1.08 Pain Relevance 0.08
This intervention significantly inhibited the accumulation of CD4(?)
Negative_regulation (inhibited) of Positive_regulation (accumulation) of CD4
5) Confidence 0.21 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.96 Pain Relevance 0.17

General Comments

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