INT140089

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.42
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
macrophage 1
pancreas 1
Stat1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 5 99.62 Very High Very High Very High
cytokine 61 99.48 Very High Very High Very High
Inflammation 47 99.28 Very High Very High Very High
Potency 53 98.90 Very High Very High Very High
agonist 23 86.24 High High
Chronic pancreatitis 2 77.24 Quite High
fibrosis 2 75.32 Quite High
Central nervous system 3 50.92 Quite High
cINOD 3 50.48 Quite High
Spinal cord 1 49.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 52 99.42 Very High Very High Very High
Primary Sclerosing Cholangitis 4 98.76 Very High Very High Very High
Apoptosis 41 97.16 Very High Very High Very High
Atherosclerosis 11 96.08 Very High Very High Very High
Shock 1 95.56 Very High Very High Very High
Injury 32 91.64 High High
Stress 5 90.88 High High
Death 64 90.40 High High
Optic Nerve Injuries 34 84.96 Quite High
Reprotox - General 1 2 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data further support the hypothesis that IFN-gamma interferes with stellate cell activation in the pancreas and suggest activated STAT1 as an inductor of a quiescent PSC phenotype.
Positive_regulation (activated) of STAT1 in pancreas associated with primary sclerosing cholangitis
1) Confidence 0.68 Published 2007 Journal Cell. Signal. Section Abstract Doc Link 17116388 Disease Relevance 0.47 Pain Relevance 0.13
STAT1 overexpression under the control of a tetracycline-dependent promoter revealed a close correlation between STAT1 expression and activation, the biological effects of IFN-gamma (growth inhibition, induction of apoptosis), and target gene expression.
Positive_regulation (activation) of STAT1 associated with apoptosis
2) Confidence 0.45 Published 2007 Journal Cell. Signal. Section Abstract Doc Link 17116388 Disease Relevance 0.42 Pain Relevance 0.16
In contrast, we observed a 7-fold reduction in potency against IL-6 driven STAT3 phosphorylation compared to activation of STAT1 by the same cytokine.
Positive_regulation (activation) of STAT1 associated with cytokine and potency
3) Confidence 0.34 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.08 Pain Relevance 0.44
activation of STAT1 through JAK1/2 or JAK1/Tyk2, respectively.
Positive_regulation (activation) of STAT1
4) Confidence 0.24 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.07 Pain Relevance 0.43
There is a strong immune-inflammatory response [54] as seen by the upregulation of JAK2, Litaf, Stat 1, and caspase 11 among others.
Positive_regulation (upregulation) of Stat 1 associated with inflammatory response
5) Confidence 0.08 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.50 Pain Relevance 0.08
was shown to inhibit monocyte [24] and macrophage [25] inflammatory responses by preventing the activation of nuclear transcription factors, such as NF-kB (nuclear factor-kappa B), AP-1 (activator protein-1) and STAT 1 (signal transducer and activator of transcription 1).
Positive_regulation (activation) of signal transducer and activator of transcription 1 in macrophage associated with inflammatory response
6) Confidence 0.07 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.87 Pain Relevance 0.34

General Comments

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