INT14009

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Context Info
Confidence 0.77
First Reported 1984
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 66
Total Number 67
Disease Relevance 19.60
Pain Relevance 37.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
interneurons 5
brain 3
macrophages 2
telencephalon 2
parabrachial nucleus 2
Sst (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 973 100.00 Very High Very High Very High
substance P 311 100.00 Very High Very High Very High
Neuropeptide 274 100.00 Very High Very High Very High
Calcitonin gene-related peptide 91 100.00 Very High Very High Very High
Enkephalin 64 100.00 Very High Very High Very High
gABA 50 100.00 Very High Very High Very High
GABAergic 42 100.00 Very High Very High Very High
Cholecystokinin 21 100.00 Very High Very High Very High
Glutamate 16 100.00 Very High Very High Very High
Serotonin 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 264 99.98 Very High Very High Very High
Adenoma 78 99.98 Very High Very High Very High
Nociception 13 99.96 Very High Very High Very High
INFLAMMATION 281 99.84 Very High Very High Very High
Cluster Headache 7 99.84 Very High Very High Very High
Granuloma 12 99.60 Very High Very High Very High
Acromegaly 216 99.52 Very High Very High Very High
Anorexia 1 99.40 Very High Very High Very High
Gallbladder Neoplasms 235 99.30 Very High Very High Very High
Ganglion Cysts 13 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, there is little information available on functional SST receptor expression in the SG neurons of the Vc in mice.
Gene_expression (expression) of SST in neurons associated with substantia gelatinosa and somatostatin
1) Confidence 0.77 Published 2009 Journal Brain Res. Section Abstract Doc Link 19782664 Disease Relevance 0.19 Pain Relevance 1.11
An i.t. injection of substance P (SP) or somatostatin (SOM) produced a characteristic behavioral response (scratching, biting, and licking).
Gene_expression (produced) of somatostatin associated with somatostatin and substance p
2) Confidence 0.75 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1715927 Disease Relevance 0.08 Pain Relevance 1.11
An i.t. injection of substance P (SP) or somatostatin (SOM) produced a characteristic behavioral response (scratching, biting, and licking).
Gene_expression (produced) of SOM associated with somatostatin and substance p
3) Confidence 0.74 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1715927 Disease Relevance 0.08 Pain Relevance 1.11
DOX and SST exhibit a synergistic inhibitory effect on the growth of gallbladder cancer cells
Gene_expression (DOX) of SST associated with gallbladder neoplasms and somatostatin
4) Confidence 0.67 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.60 Pain Relevance 0.37
After rinsing with TBS, slices were incubated with an Alexa555-coupled donkey anti-rabbit IgG (Molecular Probes,Carlsbad, CA) for BK channel detection and with an Alexa488-coupled donkey anti-goat IgG (Molecular Probes) for somatostatin detection.
Gene_expression (detection) of somatostatin associated with somatostatin
5) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.07 Pain Relevance 0.09
Somatostatin (SST), a neuropeptide produced by neuroendocrine, inflammatory, and immune cells upon triggering different responses, has been used as a regulator of many hormones in clinical studies and plays an important role in the development of various tumors [10].
Gene_expression (produced) of SST in immune cells associated with inflammation, cancer, neuropeptide and somatostatin
6) Confidence 0.60 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.96 Pain Relevance 0.30
Somatostatin (SST), a neuropeptide produced by neuroendocrine, inflammatory, and immune cells upon triggering different responses, has been used as a regulator of many hormones in clinical studies and plays an important role in the development of various tumors [10].
Gene_expression (produced) of Somatostatin in immune cells associated with inflammation, cancer, neuropeptide and somatostatin
7) Confidence 0.60 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.97 Pain Relevance 0.30
Plasma levels of SRIF in CH sufferers were lower than in control subjects.
Gene_expression (levels) of SRIF in Plasma associated with cluster headache and somatostatin
8) Confidence 0.60 Published 1987 Journal Ric Clin Lab Section Abstract Doc Link 2888182 Disease Relevance 0.73 Pain Relevance 1.15
Cells were treated with SST (75 ?
Gene_expression (treated) of SST associated with somatostatin
9) Confidence 0.59 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.26 Pain Relevance 0.08
However, the effect of SST on the growth of gallbladder cancer cells was observed at fairly high SST concentration (i.e., 75 ?
Gene_expression (concentration) of SST associated with gallbladder neoplasms and somatostatin
10) Confidence 0.59 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.69 Pain Relevance 0.47
These properties include an inward (depolarizing) current with a conductance increase in response to activation of a bradykinin receptor, an inward (depolarizing) current with a conductance increase in response to the sensory excitotoxin capsaicin, the expression of sensory neuropeptides (substance P, CGRP and somatostatin), the expression of phosphatidylinositol-anchored molecules including adhesion molecules of the immunoglobulin superfamily that can be regulated in serum-free culture by nerve growth factor (N-CAM, F-3 and Thy-1), and low permissivity to herpes simplex virus infection.
Gene_expression (expression) of somatostatin in nerve associated with qutenza, somatostatin, bradykinin, nerve growth factor, cold sores, neuropeptide, substance p and adhesions
11) Confidence 0.58 Published 1990 Journal Proc. Biol. Sci. Section Abstract Doc Link 1979443 Disease Relevance 0.44 Pain Relevance 0.45
Somatostatin and serotonin produce qualitatively different behaviors by themselves and, when administered with neurokinins, partially block neurokinin-elicited behavior.
Gene_expression (produce) of Somatostatin associated with somatostatin and serotonin
12) Confidence 0.54 Published 1988 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2455461 Disease Relevance 0.07 Pain Relevance 0.70
Epithelial cells containing gastrin and somatostatin are found during the early period of gastric and small-intestinal development.
Gene_expression (containing) of somatostatin in Epithelial cells associated with somatostatin
13) Confidence 0.52 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2408929 Disease Relevance 0.57 Pain Relevance 0.13
Together, these studies reveal somatostatin, acting through sstr2, to be one of the most potent inhibitors of electrical excitability of male and female GnRH neurons identified thus far.
Gene_expression (reveal) of somatostatin in neurons associated with somatostatin
14) Confidence 0.49 Published 2010 Journal Endocrinology Section Abstract Doc Link 20410192 Disease Relevance 0.18 Pain Relevance 0.47
In unstressed mice, i.t. injection of SP (0.1 nmol) and SST (1 nmol), respectively, produced nociceptive-related behaviors.
Gene_expression (produced) of SST associated with nociception, somatostatin and substance p
15) Confidence 0.48 Published 1993 Journal Life Sci. Section Abstract Doc Link 7681927 Disease Relevance 1.05 Pain Relevance 0.72
Vasoactive intestinal peptide (VIP), substance P, somatostatin, neurotensin, neuropeptide Y (NPY), galanin, gastrin-releasing peptide (GRP) and enkephalin were found in extracts of liver, gallbladder and bile duct.
Gene_expression (found) of somatostatin in liver associated with bile, neuropeptide, somatostatin, enkephalin and substance p
16) Confidence 0.44 Published 2000 Journal Ups. J. Med. Sci. Section Abstract Doc Link 11261606 Disease Relevance 0 Pain Relevance 0.69
Early immunohistochemical detection of somatostatin-like and methionine-enkephalin-like neuropeptides in the brain of the migratory locust embryo.
Gene_expression (detection) of somatostatin in brain associated with neuropeptide, somatostatin and enkephalin
17) Confidence 0.40 Published 1984 Journal Cell Tissue Res. Section Title Doc Link 6145522 Disease Relevance 0 Pain Relevance 0.75
GH secreting adenomas express different somatostatin receptors, as shown for example by a recent study in which 77% expressed SSTR2, 69% SSTR1 and SSTR3, and 60% SSTR5.
Gene_expression (express) of somatostatin associated with adenoma and somatostatin
18) Confidence 0.37 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.74 Pain Relevance 0.12
Somatostatin was isolated in 1973 from the hypothalamus and subsequently synthesized (Brazeau et al 1973).
Gene_expression (synthesized) of Somatostatin in hypothalamus associated with somatostatin
19) Confidence 0.37 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.69 Pain Relevance 0.46
Many benign and malign tumors express one or more somatostatin receptors.
Gene_expression (express) of somatostatin associated with cancer and somatostatin
20) Confidence 0.37 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.37 Pain Relevance 0.39

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