INT140090

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.77
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) cell adhesion (Ctgf) Golgi apparatus (Ctgf)
Anatomy Link Frequency
stellate cells 4
myocytes 2
Ctgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 5 95.92 Very High Very High Very High
Chronic pancreatitis 2 94.48 High High
cytokine 5 90.80 High High
antagonist 2 68.00 Quite High
Pain 1 50.00 Quite Low
withdrawal 2 30.00 Quite Low
Inflammation 13 25.00 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 10 99.84 Very High Very High Very High
Fibrosis 8 95.92 Very High Very High Very High
Pancreatitis 2 94.48 High High
Hyperplasia 11 94.08 High High
Pancreatic Cancer 2 93.48 High High
Hypertension 18 87.64 High High
Injury 43 79.44 Quite High
Apoptosis 1 66.84 Quite High
Stress 12 63.68 Quite High
Low Back Pain 1 62.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of CTGF expression in PSC by siRNA was associated with decreased proliferation, while application of exogenous CTGF stimulated both cell growth and collagen synthesis.
Negative_regulation (Inhibition) of Gene_expression (expression) of CTGF in PSC associated with primary sclerosing cholangitis
1) Confidence 0.58 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18639630 Disease Relevance 0.73 Pain Relevance 0.17
Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression.
Negative_regulation (down-regulation) of Gene_expression (expression) of CTGF in stellate cells
2) Confidence 0.49 Published 2007 Journal Cell. Signal. Section Title Doc Link 17116388 Disease Relevance 0.43 Pain Relevance 0.19
Their histopathological features were studied, and the expression of CTGF was assessed using immunohistochemistry.
Negative_regulation (assessed) of Gene_expression (expression) of CTGF
3) Confidence 0.43 Published 2009 Journal Spine Section Body Doc Link 19247157 Disease Relevance 0.06 Pain Relevance 0
Finally, CTGF expression was down-regulated by approximately 12.5% and 46%, respectively, after pretreatment with 1 µM and 10 µM of alagebrium (Fig. 4C).


Negative_regulation (down) of Gene_expression (expression) of CTGF
4) Confidence 0.30 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.08 Pain Relevance 0
Finally, CTGF expression was down-regulated by approximately 12.5% and 46%, respectively, after pretreatment with 1 µM and 10 µM of alagebrium (Fig. 4C).


Negative_regulation (regulated) of Gene_expression (expression) of CTGF
5) Confidence 0.30 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.08 Pain Relevance 0
And spironolactone blocked connective tissue growth factor (CTGF) expression which was inducted via p38MAPK by aldosterone in ventricular myocytes (27).
Negative_regulation (blocked) of Gene_expression (expression) of tissue growth factor in myocytes
6) Confidence 0.22 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.39 Pain Relevance 0.08

General Comments

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