INT140091

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 14.21
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) cell adhesion (Ctgf) Golgi apparatus (Ctgf)
Anatomy Link Frequency
connective tissue 5
PSC 4
intervertebral discs 2
blood 1
myocytes 1
Ctgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 8 99.84 Very High Very High Very High
fibrosis 106 99.32 Very High Very High Very High
backache 8 98.80 Very High Very High Very High
metalloproteinase 8 96.24 Very High Very High Very High
Chronic pancreatitis 6 94.48 High High
Inflammation 58 94.00 High High
cytokine 34 93.76 High High
antagonist 41 68.00 Quite High
medulla 9 55.28 Quite High
cerebral cortex 1 39.52 Quite Low
Disease Link Frequency Relevance Heat
Natriuresis 13 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 42 99.84 Very High Very High Very High
Necrosis 7 99.54 Very High Very High Very High
Cancer 28 99.36 Very High Very High Very High
Fibrosis 105 99.32 Very High Very High Very High
Myocardial Infarction 469 99.08 Very High Very High Very High
Diabetes Mellitus 357 98.84 Very High Very High Very High
Low Back Pain 8 98.80 Very High Very High Very High
Hypertension 100 98.24 Very High Very High Very High
Cardiovascular Disorder Under Development 16 97.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We do not know whether CTGF is expressed in painful disc, and related to painful disc degeneration and fibrosis.
Gene_expression (expressed) of CTGF
1) Confidence 0.78 Published 2009 Journal Spine Section Body Doc Link 19247157 Disease Relevance 0.08 Pain Relevance 0
Their histopathological features were studied, and the expression of CTGF was assessed using immunohistochemistry.
Gene_expression (expression) of CTGF
2) Confidence 0.78 Published 2009 Journal Spine Section Body Doc Link 19247157 Disease Relevance 0.06 Pain Relevance 0
Immunohistochemical staining demonstrated strong CTGF expression in the painful discs, weak expression in the asymptomatic degenerative disc, and no expression in the control discs.
Gene_expression (expression) of CTGF
3) Confidence 0.78 Published 2009 Journal Spine Section Body Doc Link 19247157 Disease Relevance 0 Pain Relevance 0
STUDY DESIGN: We collected the specimens of lumbar intervertebral discs from patients with discogenic low back pain, to study the histopathological features and connective tissue growth factor (CTGF) expressions.
Gene_expression (expressions) of connective tissue growth factor in intervertebral discs associated with low back pain and backache
4) Confidence 0.78 Published 2009 Journal Spine Section Abstract Doc Link 19247157 Disease Relevance 0.17 Pain Relevance 0.21
The strong CTGF expression in the painful disc may be related to disc fibrosis and degeneration.


Gene_expression (expression) of CTGF
5) Confidence 0.78 Published 2009 Journal Spine Section Body Doc Link 19247157 Disease Relevance 0 Pain Relevance 0
STUDY DESIGN: We collected the specimens of lumbar intervertebral discs from patients with discogenic low back pain, to study the histopathological features and connective tissue growth factor (CTGF) expressions.
Gene_expression (expressions) of CTGF in intervertebral discs associated with low back pain and backache
6) Confidence 0.78 Published 2009 Journal Spine Section Abstract Doc Link 19247157 Disease Relevance 0.17 Pain Relevance 0.21
OBJECTIVE: To study the expression and role of CTGF in fibrosis and degeneration of painful disc tissue.
Gene_expression (expression) of CTGF
7) Confidence 0.78 Published 2009 Journal Spine Section Body Doc Link 19247157 Disease Relevance 0.09 Pain Relevance 0
Inhibition of CTGF expression in PSC by siRNA was associated with decreased proliferation, while application of exogenous CTGF stimulated both cell growth and collagen synthesis.
Gene_expression (expression) of CTGF in PSC associated with primary sclerosing cholangitis
8) Confidence 0.77 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18639630 Disease Relevance 0.72 Pain Relevance 0.17
Transforming growth factor-beta1, activin A and tumor necrosis factor-alpha enhanced expression of the CTGF gene, while interferon-gamma displayed the opposite effect.
Gene_expression (expression) of CTGF gene associated with necrosis and cancer
9) Confidence 0.77 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18639630 Disease Relevance 1.12 Pain Relevance 0.19
Taken together, our results indicate a tight control of CTGF expression in PSC at the transcriptional level.
Gene_expression (expression) of CTGF in PSC associated with primary sclerosing cholangitis
10) Confidence 0.77 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18639630 Disease Relevance 0.88 Pain Relevance 0.12
In further studies, we have analyzed regulation of CTGF expression in PSC.
Spec (analyzed) Gene_expression (expression) of CTGF in PSC associated with primary sclerosing cholangitis
11) Confidence 0.77 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18639630 Disease Relevance 1.11 Pain Relevance 0.16
The mRNA expressions of p38-regulated, profibrotic connective tissue growth factor (CTGF) and proinflammatory interleukin -6 (IL-6) tended to be increased in post-MI GK rats (Figure 7C-D).


Gene_expression (expressions) of CTGF in connective tissue associated with myocardial infarction
12) Confidence 0.75 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.34 Pain Relevance 0
Expression and role of connective tissue growth factor in painful disc fibrosis and degeneration.
Gene_expression (Expression) of connective tissue growth factor in connective tissue associated with fibrosis and pain
13) Confidence 0.68 Published 2009 Journal Spine Section Title Doc Link 19247157 Disease Relevance 0.10 Pain Relevance 0.24
Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression.
Gene_expression (expression) of CTGF in stellate cells
14) Confidence 0.65 Published 2007 Journal Cell. Signal. Section Title Doc Link 17116388 Disease Relevance 0.43 Pain Relevance 0.19
CTGF stimulated binding of NF-kappaB to the IL-6 promoter, and siRNA targeting the NF-kappaB subunit RelA interfered with CTGF-induced IL-6 expression, implicating the NF-kappaB pathway in the mediation of the CTGF effect.
Gene_expression (expression) of CTGF-induced
15) Confidence 0.60 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18639630 Disease Relevance 1.03 Pain Relevance 0.15
l of cDNA was subjected to quantitative real time polymerase chain reaction using the Lightcycler® instrument (Roche diagnostics, Neuilly sur Seine, France) for detection of atrial natriuretic peptide (ANP), connective tissue growth factor (CTGF), interleukin-6 (IL-6) and ribosomal 18S mRNA.
Gene_expression (detection) of CTGF in connective tissue associated with natriuresis
16) Confidence 0.58 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.10 Pain Relevance 0
Finally, CTGF expression was down-regulated by approximately 12.5% and 46%, respectively, after pretreatment with 1 µM and 10 µM of alagebrium (Fig. 4C).


Gene_expression (expression) of CTGF
17) Confidence 0.43 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.08 Pain Relevance 0
Previous studies have indicated an increase in cardiac fibrosis in response to p38 MAPK overexpression and shown that adenoviral p38-injection into the heart increased CTGF mRNA expression [27].
Gene_expression (expression) of CTGF mRNA in heart associated with fibrosis and cardiovascular disorder under development
18) Confidence 0.40 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.24 Pain Relevance 0.17
In the present study we showed a tendency for IL-6 and CTGF mRNA expressions to be increased after MI in diabetic GK rats.
Gene_expression (expressions) of CTGF mRNA associated with diabetes mellitus and myocardial infarction
19) Confidence 0.40 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.38 Pain Relevance 0.15
CTGF is induced in adult SHR and is reduced by antihypertensive treatments [7], suggesting that CTGF expression is dependent on blood pressure.
Gene_expression (expression) of CTGF in blood
20) Confidence 0.39 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.41 Pain Relevance 0.04

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