INT14010

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 15.22
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SLC2A1) plasma membrane (SLC2A1) intracellular (SLC2A1)
carbohydrate metabolic process (SLC2A1) transmembrane transport (SLC2A1) cytoplasm (SLC2A1)
Anatomy Link Frequency
endometrium 2
plasma 1
peripheral nerves 1
capillary 1
epithelium 1
SLC2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 3 100.00 Very High Very High Very High
gABA 2 99.90 Very High Very High Very High
Somatostatin 3 99.64 Very High Very High Very High
substance P 3 99.46 Very High Very High Very High
Dismenorea 20 98.46 Very High Very High Very High
positron emission tomography 9 97.68 Very High Very High Very High
Enkephalin 2 89.80 High High
Neuropeptide 4 87.96 High High
Cholecystokinin 1 84.08 Quite High
Neurotransmitter 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 40 99.88 Very High Very High Very High
Ovarian Cancer 118 99.84 Very High Very High Very High
Endometrial Hyperplasia 10 99.84 Very High Very High Very High
Malignant Neoplastic Disease 46 99.54 Very High Very High Very High
Hyperplasia 100 99.52 Very High Very High Very High
Targeted Disruption 13 98.88 Very High Very High Very High
Cancer 294 98.76 Very High Very High Very High
Dysmenorrhea 20 98.46 Very High Very High Very High
Adenocarcinoma 32 98.28 Very High Very High Very High
Obesity 130 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the aberrant expression of GLUT-1 has been reported in a wide spectrum of epithelial malignancies, its possible correlation with the malignant transformation of endometrial epithelium has not been clearly established.
Gene_expression (expression) of GLUT-1 in epithelium associated with malignant neoplastic disease
1) Confidence 0.78 Published 2006 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 16785788 Disease Relevance 0.75 Pain Relevance 0.06
GLUT-1 was expressed in 24% (4/17 cases) of complex hyperplasia without atypia, 71% (12/17 cases) of complex hyperplasia with atypia, and 90% (28/31 cases) of adenocarcinomas.
Gene_expression (expressed) of GLUT-1 associated with adenocarcinoma and hyperplasia
2) Confidence 0.78 Published 2006 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 16785788 Disease Relevance 1.76 Pain Relevance 0.17
GLUT-1 is preferentially expressed in atypical endometrial hyperplasia and endometrial adenocarcinoma.
Gene_expression (expressed) of GLUT-1 associated with endometrial hyperplasia and endometriosis (extended)
3) Confidence 0.78 Published 2006 Journal Appl. Immunohistochem. Mol. Morphol. Section Title Doc Link 16785788 Disease Relevance 0.75 Pain Relevance 0.06
The authors conclude that GLUT-1 is preferentially expressed in complex hyperplasia with atypia and in adenocarcinoma and that GLUT-1 immunostaining is useful in distinguishing benign hyperplasia from hyperplasia strongly associated with malignancy.
Gene_expression (expressed) of GLUT-1 associated with adenocarcinoma, malignant neoplastic disease and hyperplasia
4) Confidence 0.78 Published 2006 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 16785788 Disease Relevance 1.94 Pain Relevance 0.14
The authors examined the IHC expression of GLUT-1 in cases of proliferative endometrium (n=12), secretory endometrium (n=10), endometrial polyps (n=10), adenomyosis (n=18), simple hyperplasia (n=14), complex hyperplasia without atypia (n=17), complex hyperplasia with atypia (n=17), and adenocarcinoma (n=31).
Gene_expression (expression) of GLUT-1 in endometrium associated with adenocarcinoma, endometriosis (extended), dismenorea and hyperplasia
5) Confidence 0.78 Published 2006 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 16785788 Disease Relevance 1.05 Pain Relevance 0.15
These data suggest that the expression of GLUT-1 transporter may be closely related to the malignant transformation of epithelial endometrial tumors by supporting their increased need for glucose metabolism.
Gene_expression (expression) of GLUT-1 transporter associated with malignant neoplastic disease and endometriosis (extended)
6) Confidence 0.78 Published 2006 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 16785788 Disease Relevance 1.49 Pain Relevance 0.07
GLUT-1, a high-affinity glucose transporter, is normally expressed in erythrocytes, the perineurium of peripheral nerves, and capillary endothelial cells of the blood-brain barrier.
Gene_expression (expressed) of GLUT-1 in capillary
7) Confidence 0.78 Published 2006 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 16785788 Disease Relevance 0.41 Pain Relevance 0
The purpose of this study was to evaluate the extent to which benign, hyperplastic, atypical, and malignant endometrial epithelia express GLUT-1.
Gene_expression (express) of GLUT-1 associated with malignant neoplastic disease and hyperplasia
8) Confidence 0.68 Published 2006 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 16785788 Disease Relevance 0.94 Pain Relevance 0.09
All cases from proliferative endometrium, secretory endometrium, adenomyosis, and simple hyperplasia and 90% (9/10 cases) of the endometrial polyps were negative for GLUT-1.
Neg (negative) Gene_expression (negative) of GLUT-1 in endometrium associated with endometriosis (extended), dismenorea and hyperplasia
9) Confidence 0.67 Published 2006 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 16785788 Disease Relevance 1.75 Pain Relevance 0.17
SP, NPY, SS, LANT6, GABA and GLUT), were present in neurons in dorsal cortex.
Gene_expression (present) of GLUT in cortex associated with glutamate, gaba, somatostatin and substance p
10) Confidence 0.58 Published 1991 Journal Brain Behav. Evol. Section Abstract Doc Link 1683805 Disease Relevance 0 Pain Relevance 0.83
An impact on GLUT1 expression could not be excluded but was marginal compared to the impact on GLUT4 expression.
Gene_expression (expression) of GLUT1
11) Confidence 0.41 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.78 Pain Relevance 0
The Mann-Whitney U test was used to compare GLUT1 glucose transporter expression and the plasma insulin values.
Gene_expression (expression) of GLUT1 in plasma
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797307 Disease Relevance 0.38 Pain Relevance 0
Expression of GLUT1 decreased from a median value of 1.91 [1.03–6.03] at low altitude, to 1.03 [0.68–2.14] at high altitude (arbitrary units; p<0.01; n?
Gene_expression (Expression) of GLUT1
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797307 Disease Relevance 0.09 Pain Relevance 0
GLUT1 glucose transporter expression was measured in the syncytial basal membrane by slot immunoblotting using a polyclonal antibody to GLUT1 (Chemicon, Temecula, CA) as described previously [15].
Gene_expression (expression) of GLUT1
14) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797307 Disease Relevance 0.07 Pain Relevance 0
At altitude, fetal lactate levels were increased, insulin concentrations decreased, and the expression of GLUT1 glucose transporter protein in the placental basal membrane was reduced.


Gene_expression (expression) of GLUT1
15) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797307 Disease Relevance 0.22 Pain Relevance 0
GLUT-1, a high-affinity glucose transporter, is normally expressed in erythrocytes, the perineurium of peripheral nerves, and capillary endothelial cells of the blood-brain barrier.
Gene_expression (expressed) of GLUT-1 in peripheral nerves
16) Confidence 0.26 Published 2006 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 16785788 Disease Relevance 0.41 Pain Relevance 0
Several studies have demonstrated enhanced lesion detection, SUV levels and reduced background in PET scans performed after rhTSH stimulation, reviewed recently by Leboulleux et al (2007), presumably due to increased GLUT1 synthesis and glucose transport stimulated by TSH action.
Gene_expression (synthesis) of GLUT1 associated with positron emission tomography
17) Confidence 0.24 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0.28 Pain Relevance 0.32
GLUT1 in particular is highly expressed in ovarian cancer [78], where tumour status (benign, borderline, or malignant) is correlated with the level of GLUT1 expression [79].
Gene_expression (expressed) of GLUT1 associated with malignant neoplastic disease, cancer and ovarian cancer
18) Confidence 0.13 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2825545 Disease Relevance 1.05 Pain Relevance 0.03
GLUT1 in particular is highly expressed in ovarian cancer [78], where tumour status (benign, borderline, or malignant) is correlated with the level of GLUT1 expression [79].
Gene_expression (expression) of GLUT1 associated with malignant neoplastic disease, cancer and ovarian cancer
19) Confidence 0.13 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2825545 Disease Relevance 1.08 Pain Relevance 0.03

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