INT140107

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.11
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnfrsf1b) cell death (Tnfrsf1b) nucleus (Tnfrsf1b)
Anatomy Link Frequency
fat 1
neurons 1
Tnfrsf1b (Mus musculus)
Pain Link Frequency Relevance Heat
allodynia 4 99.82 Very High Very High Very High
dorsal root ganglion 22 99.76 Very High Very High Very High
Cancer pain 1 98.94 Very High Very High Very High
Thermal hyperalgesia 5 98.30 Very High Very High Very High
Hyperalgesia 4 98.02 Very High Very High Very High
Multiple sclerosis 38 96.88 Very High Very High Very High
Sciatic nerve 3 94.80 High High
Dorsal horn 16 93.88 High High
Spinal cord 27 93.76 High High
Eae 4 93.72 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 36 99.96 Very High Very High Very High
Neuropathic Pain 9 99.82 Very High Very High Very High
Ganglion Cysts 22 99.76 Very High Very High Very High
Cancer Pain 1 98.94 Very High Very High Very High
Hyperalgesia 9 98.30 Very High Very High Very High
Demyelinating Disease 48 96.88 Very High Very High Very High
Obesity 8 95.92 Very High Very High Very High
Injury 17 93.72 High High
Weight Gain 38 93.36 High High
INFLAMMATION 67 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found an absence of thermal hyperalgesia in mice deficient of TNFR1 and a reduction in mechanical and cold allodynia in mice deficient of TNFR1 or TNFR2 compared with wild-type mice.
Negative_regulation (deficient) of TNFR2 associated with allodynia and thermal hyperalgesia
1) Confidence 0.36 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 17117937 Disease Relevance 1.03 Pain Relevance 0.77
These important findings in pre-clinical models have clinical implications and suggest that inhibition of tmTNF/TNFR2 signaling by lenercept was the molecular basis for the worsening symptoms in MS patients.
Negative_regulation (inhibition) of TNFR2 associated with multiple sclerosis
2) Confidence 0.30 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.77 Pain Relevance 0.29
Other TACE inhibitors including BMS-561392 have been delayed from clinical trials due to the potential risk of hepatoxicity resulting from the accumulation of tmTNF and the inhibition of TNFR1 and TNFR2 shedding which was demonstrated in rats treated with TACE inhibitors (reviewed in [121]).


Negative_regulation (inhibition) of TNFR2
3) Confidence 0.30 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.72 Pain Relevance 0.39
A role for TNFR2 receptors in heat hyperalgesia has been implicated in a model of cancer pain where TRPV1 protein up-regulation in DRG neurons is attenuated in TNFR2 knock-out mice [4].
Negative_regulation (attenuated) of TNFR2 in neurons associated with targeted disruption, dorsal root ganglion, hyperalgesia and cancer pain
4) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2936303 Disease Relevance 1.67 Pain Relevance 1.36
Increasing prealbumin correlated with reduction in TNFR-p55 and TNFR-p75 (Yeh et al 2000b, 2001).
Negative_regulation (reduction) of TNFR-p75
5) Confidence 0.04 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676640 Disease Relevance 1.03 Pain Relevance 0.19
Increasing weight/fat free mass correlated with reduction in sIL-2r and TNFR-p75 (Yeh et al 2001).
Negative_regulation (reduction) of TNFR-p75 in fat
6) Confidence 0.04 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676640 Disease Relevance 0.90 Pain Relevance 0.21

General Comments

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