INT140113

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.57
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gfra4) extracellular region (Gfra4) plasma membrane (Gfra4)
Anatomy Link Frequency
sympathetic 1
DRG 1
motor neurons 1
dorsal horn 1
Gfra4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 4 99.96 Very High Very High Very High
Dorsal horn 6 97.72 Very High Very High Very High
c fibre 8 96.24 Very High Very High Very High
Neuropeptide 2 95.08 Very High Very High Very High
Pain 6 92.92 High High
Catecholamine 1 78.40 Quite High
Spinal cord 2 75.00 Quite High
substance P 1 69.76 Quite High
Neuropathic pain 4 64.84 Quite High
qutenza 1 61.60 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 99.96 Very High Very High Very High
Frailty 8 99.28 Very High Very High Very High
Nervous System Injury 11 97.00 Very High Very High Very High
Pain 4 92.92 High High
Hypersensitivity 1 87.32 High High
Injury 6 86.88 High High
Neuropathic Pain 4 64.84 Quite High
Nociception 2 61.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The artemin receptor, GFRalpha3, is present in both sympathetic efferents and a subpopulation of nociceptive afferents.
Gene_expression (present) of GFRalpha3 in sympathetic
1) Confidence 0.37 Published 2010 Journal Headache Section Body Doc Link 19845789 Disease Relevance 0 Pain Relevance 0
CGRP-LI and transient receptor potential ion channel 1 (TRPV1)-LI were present in all GFRalpha3-positive dural afferents, which constituted 22% of the total population of dural afferents.
Gene_expression (present) of GFRalpha3
2) Confidence 0.32 Published 2010 Journal Headache Section Body Doc Link 19845789 Disease Relevance 0 Pain Relevance 0
In contrast, in GFRalpha2-expressing nonpeptidergic afferents SCI caused a permanent loss of dorsal horn innervation.
Gene_expression (expressing) of GFRalpha2 in dorsal horn associated with frailty and dorsal horn
3) Confidence 0.24 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17640046 Disease Relevance 1.02 Pain Relevance 0.61
As the artemin high-affinity receptor GFRalpha-3 is present in Schwann cells and not in motor neurons, the effect on motor neuron axon regeneration may result from an indirect effect through Schwann cells in the injured nerve.
Neg (not) Gene_expression (present) of GFRalpha-3 in motor neurons
4) Confidence 0.09 Published 2009 Journal Scand J Plast Reconstr Surg Hand Surg Section Abstract Doc Link 19863426 Disease Relevance 0.88 Pain Relevance 0.33
Interestingly, only 30% of GFRalpha3-expressing DRG cells co-expressed RET (the signal transducing domain).
Gene_expression (expressing) of GFRalpha3-expressing in DRG associated with dorsal root ganglion
5) Confidence 0.05 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 17117942 Disease Relevance 0.66 Pain Relevance 0.83

General Comments

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