INT140142

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Context Info
Confidence 0.63
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 3.78
Pain Relevance 5.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
spinal 3
pyramidal neurons 1
Mouse 1
filament 1
spinal cord dorsal horn 1
Sigmar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 39 100.00 Very High Very High Very High
agonist 84 99.84 Very High Very High Very High
Central nervous system 5 99.68 Very High Very High Very High
Kinase C 25 99.08 Very High Very High Very High
nMDA receptor 34 98.08 Very High Very High Very High
fortral 79 97.78 Very High Very High Very High
long-term potentiation 11 97.28 Very High Very High Very High
Spinal cord 6 96.48 Very High Very High Very High
Dorsal horn 6 96.00 Very High Very High Very High
Pyramidal cell 21 94.92 High High
Disease Link Frequency Relevance Heat
Cancer 92 99.40 Very High Very High Very High
Pain 31 98.32 Very High Very High Very High
Pancreatic Cancer 29 96.10 Very High Very High Very High
Nociception 12 95.88 Very High Very High Very High
Adhesions 80 93.48 High High
Stress 17 91.36 High High
Apoptosis 47 89.52 High High
Breast Cancer 1 78.56 Quite High
Metastasis 18 72.76 Quite High
Hyperplasia 1 71.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mouse and human pancreatic cancer cell lines as well as established Panc-02 tumor allografts established in C57Bl/6 mice expressed the sigma-2 receptor at significantly higher levels than normal mouse tissues, and the selective accumulation of the sigma-2 receptor ligand in the tumor could be used to image the tumor in vivo.
Positive_regulation (accumulation) of sigma-2 receptor in Mouse associated with cancer and pancreatic cancer
1) Confidence 0.63 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 1.75 Pain Relevance 0.08
Incubation of cells with NO and ROS donors markedly increased sigmaR1 binding activity.
Positive_regulation (increased) of sigmaR1
2) Confidence 0.50 Published 2006 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17122151 Disease Relevance 0 Pain Relevance 0
We also showed that activation of spinal sigma-1 receptors increased the phosphorylation of the NMDA receptor NR1 subunit (pNR1) in the spinal cord dorsal horn, which resulted in the potentiation of NMDA receptor function.
Positive_regulation (activation) of sigma-1 in spinal cord dorsal horn associated with nmda receptor, dorsal horn and spinal cord
3) Confidence 0.44 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.17 Pain Relevance 0.63
The sigma-1 receptor is widely distributed in the central nervous system and periphery.
Positive_regulation (distributed) of sigma-1 receptor in central nervous system associated with central nervous system
4) Confidence 0.44 Published 2009 Journal Science Section Abstract Doc Link 19213917 Disease Relevance 0 Pain Relevance 0.18
On the other hand, activation of sigma-1 receptors resulted in upregulation of the FRA-2 gene[15,16], a member of the AP-1 subfamily.
Positive_regulation (activation) of sigma-1
5) Confidence 0.44 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.22 Pain Relevance 0.16
Interestingly, stabilization of F-Actin by phalloidin led to an increase in the level of talin and sigma-1 receptors together in FAC.
Positive_regulation (increase) of sigma-1
6) Confidence 0.38 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.28 Pain Relevance 0.18
Conversely, the sigma-1 receptor activation of the PKCzeta isoform appears to be involved in a pain signaling pathway that is independent of spinal pNR1 modulation.
Positive_regulation (activation) of sigma-1 receptor in spinal associated with pain
7) Confidence 0.37 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.34 Pain Relevance 0.77
Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCalpha and epsilon, but not the PKCzeta, isoforms.
Positive_regulation (increase) of Sigma-1 receptor in spinal associated with pain
8) Confidence 0.34 Published 2010 Journal Neurosci. Lett. Section Title Doc Link 20417251 Disease Relevance 0.22 Pain Relevance 0.87
These findings demonstrate that the sigma-1 receptor-induced increase in spinal pNR1 expression is mediated by the PKCalpha and PKC epsilon isoforms, which in turn contribute to the pain facilitation phenomenon.
Positive_regulation (increase) of sigma-1 receptor in spinal associated with pain and kinase c
9) Confidence 0.34 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.31 Pain Relevance 0.86
In CHO-K1 cells following various treatment with (+)-pentazocine, iodoazidococaine and phalloidin (which directly stabilizes F-Actin) we observed that there was a significant increase of the level of sigma-1 receptors in the FAC (Fig. 4.).
Positive_regulation (increase) of sigma-1 associated with fortral
10) Confidence 0.29 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0 Pain Relevance 0.26
The increase of sigma-1 receptors in FAC induced by the irreversible phalloidin F-actin polymerization indicated that the sigma-1 receptors are stabilized in FAC by F-actin polymerization.
Positive_regulation (stabilized) of sigma-1
11) Confidence 0.29 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.15 Pain Relevance 0.12
Following direct actin filament stabilization with phalloidin a doubling of the level of talin in the FAC was observed, while the sigma-1 receptor levels in the FAC increased more than 6 fold (Fig. 4.).
Positive_regulation (increased) of sigma-1 receptor in filament
12) Confidence 0.29 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0 Pain Relevance 0.22
Since the increase in sigma-1 receptors in FAC upon addition of sigma-1 receptor ligands occured in a relatively short period of time (30 min), we hypothesized that this relocation may be due to recruitment of receptors from intracellular pools.
Positive_regulation (increase) of sigma-1
13) Confidence 0.29 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0 Pain Relevance 0.21
Only sigma-1 receptor ligands, however, resulted in an increase of sigma-1 receptors in the FAC, independent of talin.
Positive_regulation (increase) of sigma-1
14) Confidence 0.29 Published 2007 Journal J Mol Signal Section Abstract Doc Link PMC2045653 Disease Relevance 0.25 Pain Relevance 0.04
When the cells were rinsed with DMEM (without serum), instead of DPBS, the appearance of the sigma-1 receptors was also preserved in FAC, leading to the conclusion that the presence of divalent cations stabilized the sigma-1 receptors in the FAC, but did not appear to stimulate translocation of the sigma-1 receptors to the FAC.
Neg (not) Positive_regulation (stabilized) of sigma-1
15) Confidence 0.29 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.08 Pain Relevance 0.11
Finally, a recent study showed that sigma-1 receptor activation leads to the inhibition of SK channel activity, resulting in a potentiation of NMDA receptor-mediated currents and LTP in CA1 pyramidal neurons [118].
Positive_regulation (activation) of sigma-1 receptor in pyramidal neurons associated with pyramidal cell, nmda receptor and long-term potentiation
16) Confidence 0.03 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.33
Sigma1 receptor activation by agonists induces the dissociation of the ?
Positive_regulation (activation) of Sigma1 associated with agonist
17) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701284 Disease Relevance 0 Pain Relevance 0.25

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