INT140164

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.78
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cx3cr1) signal transducer activity (Cx3cr1)
Anatomy Link Frequency
nerve 2
spinal cord 2
microglia 2
Cx3cr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 8 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Neuritis 3 99.84 Very High Very High Very High
Eae 6 99.76 Very High Very High Very High
Dorsal horn 1 99.00 Very High Very High Very High
Pain 9 98.96 Very High Very High Very High
intrathecal 1 97.84 Very High Very High Very High
allodynia 4 95.60 Very High Very High Very High
Sciatic nerve 1 95.12 Very High Very High Very High
IPN 2 93.64 High High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 3 99.84 Very High Very High Very High
Injury 6 99.76 Very High Very High Very High
Pain 7 98.96 Very High Very High Very High
Neuropathic Pain 8 95.60 Very High Very High Very High
Inflammatory Pain 2 93.64 High High
Hyperalgesia 2 88.56 High High
Nervous System Injury 4 87.24 High High
Disease 1 84.80 Quite High
INFLAMMATION 1 84.48 Quite High
Syndrome 2 83.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis revealed that CX3CR1 expression in the spinal cord was significantly increased following CFA-induced MA.
Positive_regulation (increased) of Gene_expression (expression) of CX3CR1 in spinal cord associated with spinal cord
1) Confidence 0.70 Published 2007 Journal Pain Section Abstract Doc Link 17123734 Disease Relevance 0.61 Pain Relevance 0.88
The expression of the chemokine CX3CL1 (fractalkine) and its receptor CX3CR1 were also higher in EAN than in control dorsal horns suggesting spinal microglia and CX3CL1/CX3CR1 may play a role in the pain-like behaviour.
Positive_regulation (higher) of Gene_expression (expression) of CX3CR1 in microglia associated with pain, chemokine and neuritis
2) Confidence 0.50 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18448252 Disease Relevance 1.06 Pain Relevance 0.89
The increases in CX3CR1 expression, p38 MAPK activation and pain behavior after CCI were suppressed by blocking IL-6 action with a neutralizing antibody, while they were enhanced by supplying exogenous recombinant rat IL-6 (rrIL-6). rrIL-6 also induced increases in spinal CX3CR1 expression, p38 MAPK activation and pain behavior in nai ve rats without nerve injury.
Positive_regulation (increases) of Gene_expression (expression) of CX3CR1 in nerve associated with pain, nervous system injury and eae
3) Confidence 0.44 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19959384 Disease Relevance 1.12 Pain Relevance 0.88

General Comments

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