INT140168

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.55
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cx3cl1, Cx3cr1) extracellular space (Cx3cl1) extracellular region (Cx3cl1)
signal transducer activity (Cx3cr1) cytoplasm (Cx3cl1)
Anatomy Link Frequency
plaque 3
spinal cord 1
Cx3cl1 (Rattus norvegicus)
Cx3cr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 1 100.00 Very High Very High Very High
Angina 6 98.12 Very High Very High Very High
Spinal cord 2 97.36 Very High Very High Very High
Pain 5 94.68 High High
Neuropathic pain 1 76.64 Quite High
glial activation 1 75.00 Quite High
IPN 2 70.00 Quite High
intrathecal 1 48.64 Quite Low
allodynia 1 40.48 Quite Low
Thermal hyperalgesia 1 39.36 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerosis 3 99.80 Very High Very High Very High
Rupture 6 99.12 Very High Very High Very High
Cv General 3 Under Development 6 98.12 Very High Very High Very High
Pain 3 94.68 High High
Neuropathic Pain 2 76.64 Quite High
Inflammatory Pain 2 70.00 Quite High
Hyperalgesia 1 39.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fractalkine, a chemokine binding to only one known receptor CX3CR1, has recently been proposed to be a neuron-to-glia signal in the spinal cord leading to microglial activation and glially dependent pain facilitation.
Fractalkine Binding (binding) of CX3CR1 in spinal cord associated with pain, chemokine and spinal cord
1) Confidence 0.31 Published 2007 Journal Pain Section Abstract Doc Link 17123734 Disease Relevance 0.32 Pain Relevance 0.48
Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris.
fractalkine Binding (associated) of CX3CR1 in plaque associated with angina and rupture
2) Confidence 0.12 Published 2010 Journal Circ. J. Section Title Doc Link 20019415 Disease Relevance 0.39 Pain Relevance 0.20
BACKGROUND: Recent studies suggest that fractalkine (FKN or CX3CL1) and its cognate receptor, CX3CR1, play a role in atherogenesis, so the relationship between coronary plaque rupture, as observed by preintervention optical coherence tomography, and plasma levels of FKN and CX3CR1 was investigated in this study.
CX3CL1 Binding (receptor) of CX3CR1 in plaque associated with rupture and atherosclerosis
3) Confidence 0.11 Published 2010 Journal Circ. J. Section Abstract Doc Link 20019415 Disease Relevance 0.42 Pain Relevance 0.15
BACKGROUND: Recent studies suggest that fractalkine (FKN or CX3CL1) and its cognate receptor, CX3CR1, play a role in atherogenesis, so the relationship between coronary plaque rupture, as observed by preintervention optical coherence tomography, and plasma levels of FKN and CX3CR1 was investigated in this study.
fractalkine Binding (receptor) of CX3CR1 in plaque associated with rupture and atherosclerosis
4) Confidence 0.09 Published 2010 Journal Circ. J. Section Abstract Doc Link 20019415 Disease Relevance 0.42 Pain Relevance 0.15

General Comments

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