INT140170

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 36.16
Pain Relevance 6.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) cytoplasm (Nqo1)
Anatomy Link Frequency
spinal cord 3
face 1
eosinophil 1
midbrain 1
optic nerves 1
Nqo1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 345 99.96 Very High Very High Very High
Central nervous system 603 99.84 Very High Very High Very High
Multiple sclerosis 283 99.80 Very High Very High Very High
midbrain 10 99.62 Very High Very High Very High
Neuritis 311 99.20 Very High Very High Very High
imagery 38 98.20 Very High Very High Very High
Inflammation 290 98.16 Very High Very High Very High
Demyelination 46 90.88 High High
tolerance 27 87.76 High High
medulla 28 81.44 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 2643 100.00 Very High Very High Very High
Syndrome 87 100.00 Very High Very High Very High
Autoimmune Disease 236 99.98 Very High Very High Very High
Systemic Lupus Erythematosus 110 99.98 Very High Very High Very High
Central Nervous System Disease 44 99.84 Very High Very High Very High
Demyelinating Disease 331 99.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 99.76 Very High Very High Very High
Disease 892 99.52 Very High Very High Very High
Infection 172 99.52 Very High Very High Very High
Optic Neuritis 303 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This antibody has not yet been proven to be pathogenic, but several facts suggest that it might be, including the similarity of the immunohistochemical pattern of NMO-(AQP4) IgG binding to mouse CNS tissues to the pattern of immune complex deposition in autopsied patients' spinal cord tissue.
NMO Binding (binding) of in spinal cord associated with neuromyelitis optica and spinal cord
1) Confidence 0.38 Published 2006 Journal Dis. Markers Section Abstract Doc Link 17124341 Disease Relevance 1.18 Pain Relevance 0.35
We recently discovered a unique IgG autoantibody (NMO-IgG) that is highly specific to patients with NMO and thus a valuable diagnostic aid.
NMO-IgG Binding (specific) of associated with neuromyelitis optica
2) Confidence 0.29 Published 2006 Journal Dis. Markers Section Abstract Doc Link 17124341 Disease Relevance 1.17 Pain Relevance 0.20
We recently discovered a unique IgG autoantibody (NMO-IgG) that is highly specific to patients with NMO and thus a valuable diagnostic aid.
NMO-IgG Binding (specific) of associated with neuromyelitis optica
3) Confidence 0.29 Published 2006 Journal Dis. Markers Section Abstract Doc Link 17124341 Disease Relevance 1.17 Pain Relevance 0.20
Detection of NMO-IgG or AQP4 autoantibodies is clinically useful for early diagnosis of NMO and its related spectrum disorders (NMOSD), including single attack or recurrent LETM without ON, and recurrent ON without ATM; and especially early distinction between NMOSD and CMS [3].
NMO Binding (diagnosis) of associated with neuromyelitis optica, multiple sclerosis, transverse myelitis, demyelinating disease and neuritis
4) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 2.28 Pain Relevance 0.62
However, it is now recognized that a majority of NMO patients develop autoantibodies (NMO-IgG) against aquaporin 4 (AQP4) [4].
NMO-IgG Binding (recognized) of associated with neuromyelitis optica
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 1.08 Pain Relevance 0.23
In contrast to the characteristic intense staining of pial and microvascular elements in the brain, NMO-IgG did not bind to any vascular or visceral autonomic neural elements in these organs.
NMO Neg (not) Binding (bind) of in neural associated with neuromyelitis optica
6) Confidence 0.03 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.93 Pain Relevance 0.03
Finally, our findings suggest that testing for AQP4 antibodies not only enables a reliable distinction to be made between NMO and MS, but also facilitates differential diagnosis concerning other autoimmune diseases affecting the CNS.
NMO Binding (made) of associated with neuromyelitis optica, multiple sclerosis, autoimmune disease and central nervous system
7) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1852124 Disease Relevance 1.98 Pain Relevance 0.32
Recently, however, a biomarker for NMO was identified.
NMO Binding (biomarker) of associated with neuromyelitis optica
8) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1852124 Disease Relevance 2.02 Pain Relevance 0.44
Many patients with NMO make autoantibodies (proteins that recognize a component of a person's own tissues) called NMO-IgGs.
NMO Binding (recognize) of associated with neuromyelitis optica
9) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1852124 Disease Relevance 1.87 Pain Relevance 0.33
A serum autoantibody (called NMO-IgG) binding to CNS microvessels, pia, subpia, and Virchow-Robin spaces was recently identified in patients with NMO, using indirect immunofluorescence [6].
NMO Binding (binding) of associated with neuromyelitis optica and central nervous system
10) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1852124 Disease Relevance 2.01 Pain Relevance 0.51
NMO-IgG bound to an antigen in the abluminal face of cerebral microvessels, an area represented by astrocytic foot processes.
NMO Binding (bound) of in face associated with neuromyelitis optica
11) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.07 Pain Relevance 0.22
In white and grey matter of the cerebellum, midbrain, and spinal cord, NMO-IgG bound in a linear pattern along pial membranes, extending into the Virchow-Robin spaces, the abluminal surface of cerebral microvessels, and the subpial region with a mesh pattern.
NMO Binding (bound) of in cerebellum associated with neuromyelitis optica, midbrain and spinal cord
12) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.14 Pain Relevance 0.23
The autoimmune diseases associated with NMO can be either organ specific (Myasthenia Gravis, MG) or systemic (Systemic Lupus Erythematosus, SLE) but have a common characteristic of the involvement of autoantibodies specific for a panel of extracellular and intracellular antigens.
NMO Binding (associated) of associated with neuromyelitis optica, autoimmune disease, myasthenia gravis and systemic lupus erythematosus
13) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 2.08 Pain Relevance 0.20
While not common, NMO has been associated with HIV-1 infection in an African woman [122].
NMO Binding (associated) of associated with neuromyelitis optica, acquired immune deficiency syndrome or hiv infection and infection
14) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 2.65 Pain Relevance 0.15
Classically, NMO targets the spinal cord and optic nerves and spares the brain.
NMO Binding (targets) of in spinal cord associated with neuromyelitis optica and spinal cord
15) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.84 Pain Relevance 0.37
Alternatively, is NMO a syndrome with distinct but multiple causes triggered by multiple distinct antigens that induce autoreactive T cells and high affinity antibodies?
NMO Binding (syndrome) of in T cells associated with neuromyelitis optica and syndrome
16) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.33 Pain Relevance 0.28
NMO in association with other diseases
NMO Binding (association) of associated with neuromyelitis optica and disease
17) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.66 Pain Relevance 0.21
The elevation of these molecules was not specific to NMO as other neurologic conditions have elevated eosinophil chemotactic factors in the CSF.


NMO Binding (specific) of in eosinophil associated with neuromyelitis optica
18) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.08 Pain Relevance 0.21
Most of the reported cases of SLE associated with NMO were prior to the identification and use of NMO-IgG1 as a diagnostic tool.
NMO Binding (associated) of associated with neuromyelitis optica and systemic lupus erythematosus
19) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 2.52 Pain Relevance 0.04
Thus an AQP4 animal model would provide a means to manipulate events which are now associated with NMO and thus demonstrate what set of events or multiplicity of events can push the anti-AQP4 response to be pathogenic.



NMO Binding (associated) of associated with neuromyelitis optica
20) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.19 Pain Relevance 0.12

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