INT140171

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 19
Disease Relevance 11.63
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
T cells 7
retinas 1
B cell 1
spinal cord 1
brain 1
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 4 99.24 Very High Very High Very High
Spinal cord 50 96.44 Very High Very High Very High
Inflammation 176 94.72 High High
Glutamate receptor 13 93.40 High High
Inflammatory response 13 92.24 High High
Central nervous system 31 91.76 High High
Neuritis 86 86.92 High High
cytokine 44 81.76 Quite High
Multiple sclerosis 48 77.84 Quite High
cva 7 65.52 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 426 99.96 Very High Very High Very High
Immunization 84 97.98 Very High Very High Very High
Dementia 10 96.96 Very High Very High Very High
Death 2 96.64 Very High Very High Very High
Epilepsy 10 96.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 96.32 Very High Very High Very High
INFLAMMATION 179 94.72 High High
Sprains And Strains 84 91.76 High High
Autism 16 91.44 High High
Disease 82 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, MetaSVMp did not predict T cell recognition of AQP4 166-180 or 261-280.
AQP4 Binding (recognition) of in T cell
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.26 Pain Relevance 0
This antibody has not yet been proven to be pathogenic, but several facts suggest that it might be, including the similarity of the immunohistochemical pattern of NMO-(AQP4) IgG binding to mouse CNS tissues to the pattern of immune complex deposition in autopsied patients' spinal cord tissue.
AQP4 Binding (binding) of in spinal cord associated with neuromyelitis optica and spinal cord
2) Confidence 0.35 Published 2006 Journal Dis. Markers Section Abstract Doc Link 17124341 Disease Relevance 1.18 Pain Relevance 0.35
RESULTS: Serum IgG from patients with NMO binds to the extracellular domain of aquaporin-4; it is predominantly IgG(1), and it initiates two potentially competing outcomes, aquaporin-4 endocytosis/degradation and complement activation.
aquaporin-4 Binding (binds) of
3) Confidence 0.34 Published 2007 Journal Neurology Section Body Doc Link 17928579 Disease Relevance 0 Pain Relevance 0
However, further studies are required to clarify the expression and functional interaction of AQP4 and Kir4.1 in the hippocampus and their changes during epileptogenesis.
AQP4 Binding (interaction) of in hippocampus associated with hippocampus
4) Confidence 0.34 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.55 Pain Relevance 0.05
Upregulation of utrophin may partially compensate Dp71 deficiency by interacting with AQP4 and Kir4.1 in retinas and isolated Müller cells of mice [14].
AQP4 Binding (interacting) of in retinas
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.22 Pain Relevance 0
Using Western Blot analysis, Hillaire and collaborators [88] showed that immunoreactivity for AQP4 is elevated in brain homogenates from the mid frontal gyrus of patients who died with HIVD.
AQP4 Binding (immunoreactivity) of in brain associated with dementia
6) Confidence 0.32 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.50 Pain Relevance 0.10
AQP4 p21-40 ranked among the top 12 percentile of predicted I-Ab-binding AQP4 15-mers (Figure 6A bottom panel).
AQP4 Binding (binding) of
7) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.19 Pain Relevance 0
Although intriguing, T cell recognition of this same region of AQP4 is probably coincidental, since determinants recognized by CD4+ T cells are generally created through processing and association with MHC II molecules [16].
AQP4 Binding (recognition) of in T cells
8) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0 Pain Relevance 0.05
Thus, in parallel with our analysis by direct immunization of AQP4 peptides, C57BL/6 and SJL/J mice were separately immunized with intact AQP4, and tested for recall to intact AQP4 and the individual overlapping AQP4 peptides.
AQP4 Binding (recall) of associated with immunization
9) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.38 Pain Relevance 0
Thus, in parallel with our analysis by direct immunization of AQP4 peptides, C57BL/6 and SJL/J mice were separately immunized with intact AQP4, and tested for recall to intact AQP4 and the individual overlapping AQP4 peptides.
AQP4 Binding (recall) of associated with immunization
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.44 Pain Relevance 0
T cells that proliferated to AQP4 were CD4+ and MHC II-restricted (data not shown).
AQP4 Binding (proliferated) of in T cells
11) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.15 Pain Relevance 0
Specifically, we did not identify T cell determinants within the three extracellular domains, the A, C, and E loops [17], which may contain B cell determinants recognized by AQP4-specific antibodies from NMO patients [18].


AQP4 Binding (recognized) of in B cell associated with neuromyelitis optica
12) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.23 Pain Relevance 0
Although little is known regarding recognition of AQP4 by T cells, AQP4-specific T cells may drive the humoral AQP4-specific immune response.
AQP4 Binding (recognition) of in T cells
13) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 1.47 Pain Relevance 0.32
The identification of regions of AQP4 recognized in mice may also provide insights regarding recognition of human AQP4 by NMO patients.


AQP4 Binding (recognized) of associated with neuromyelitis optica
14) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.82 Pain Relevance 0.14
Our goal in this investigation was to characterize T cell recognition of AQP4.
AQP4 Binding (recognition) of in T cell
15) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 1.57 Pain Relevance 0.23
MetaSVMp, a program that utilizes relative affinities of identified determinants from the immune epitope database (IEDB) to predict MHC II binding peptides [26], [27], [30], identified eight distinct regions of AQP4 that contain potential determinants that bind I-Ab for T cell recognition (Figure 6A top panel).
AQP4 Binding (bind) of in T cell
16) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.12 Pain Relevance 0
AQP4 p21-40 is the naturally processed immunodominant determinant for recognition by CD4+ T cells
AQP4 Binding (recognition) of in T cells
17) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.23 Pain Relevance 0
The identification of regions of AQP4 recognized in mice may also provide insights regarding recognition of human AQP4 by NMO patients.


AQP4 Binding (recognition) of associated with neuromyelitis optica
18) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.75 Pain Relevance 0.14
Anti-AQP4 antibody has been shown to react with AQP4 expressed on astrocytes, inducing complement fixation reaction and leading to cell death [2].
AQP4 Binding (react) of in astrocytes associated with death
19) Confidence 0.14 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964037 Disease Relevance 1.57 Pain Relevance 0.60

General Comments

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