INT140172

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 6.68
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) cytoplasm (Nqo1)
Anatomy Link Frequency
spinal cord 1
Nqo1 (Mus musculus)
IgG (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 184 97.92 Very High Very High Very High
Spinal cord 96 97.76 Very High Very High Very High
Inflammation 57 92.72 High High
Demyelination 10 79.36 Quite High
Neuritis 80 75.68 Quite High
Multiple sclerosis 55 75.44 Quite High
tolerance 9 62.80 Quite High
cytokine 17 44.48 Quite Low
addiction 3 34.52 Quite Low
ischemia 2 29.84 Quite Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 711 100.00 Very High Very High Very High
Targeted Disruption 65 98.72 Very High Very High Very High
Autoimmune Disease 67 97.60 Very High Very High Very High
Disease 226 96.16 Very High Very High Very High
INFLAMMATION 60 92.72 High High
Necrosis 8 92.32 High High
Genetic Predisposition To Disease 3 90.40 High High
Infection 57 89.44 High High
Immunization 18 85.16 High High
Demyelinating Disease 38 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This antibody has not yet been proven to be pathogenic, but several facts suggest that it might be, including the similarity of the immunohistochemical pattern of NMO-(AQP4) IgG binding to mouse CNS tissues to the pattern of immune complex deposition in autopsied patients' spinal cord tissue.
NMO Binding (binding) of IgG in spinal cord associated with neuromyelitis optica and spinal cord
1) Confidence 0.17 Published 2006 Journal Dis. Markers Section Abstract Doc Link 17124341 Disease Relevance 1.18 Pain Relevance 0.35
The limited access of circulating IgG to the extracapillary space in the CNS would only permit interaction of NMO-IgG with AQP4 at the glia limitans of BBB: in consequence of these findings, many authors suggest the perivascular space as the primary target site of the pathogenic process.
NMO Binding (interaction) of IgG associated with neuromyelitis optica
2) Confidence 0.00 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.09 Pain Relevance 0.17
A small animal model of NMO is essential to demonstrate whether AQP4 is indeed the incipient autoantigen capable of inducing NMO-IgG formation and NMO.
NMO Binding (formation) of NMO-IgG associated with neuromyelitis optica
3) Confidence 0.00 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.85 Pain Relevance 0.32
However the perivascular IgM, IgG, and complement products associated with human NMO were not present in the double transgenic model, nor were anti-AQP4 antibodies [130].
NMO Binding (associated) of IgG associated with targeted disruption and neuromyelitis optica
4) Confidence 0.00 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.45 Pain Relevance 0.23
The available data does not show a clearly defined mechanism explaining the association of NMO-IgG and NMO.
NMO Binding (association) of NMO-IgG associated with neuromyelitis optica
5) Confidence 0.00 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.12 Pain Relevance 0.13

General Comments

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