INT140175

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 8.59
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Anatomy Link Frequency
platelet 2
interstitial cells 1
internal 1
stem cell 1
reticulum 1
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 20 100.00 Very High Very High Very High
Dismenorea 5 99.98 Very High Very High Very High
Spinal cord 4 93.08 High High
cytokine 5 93.00 High High
shoulder pain 9 88.32 High High
addiction 2 83.60 Quite High
pain flank 1 78.48 Quite High
intrathecal 3 76.44 Quite High
withdrawal 2 74.28 Quite High
melanocortin 1 receptor 33 74.00 Quite High
Disease Link Frequency Relevance Heat
Pain 22 100.00 Very High Very High Very High
Dysmenorrhea 5 99.98 Very High Very High Very High
Gastrointestinal Stromal Tumor 113 99.66 Very High Very High Very High
Disease 56 97.32 Very High Very High Very High
Stress 24 96.68 Very High Very High Very High
Hematological Disease 75 94.64 High High
Anaemia 65 94.24 High High
Apoptosis 21 94.08 High High
Myeloid Leukemia 52 92.48 High High
Cancer 293 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the data support that the mutants described here represent a new allelic series at the Kit locus, with three missense mutations (Sco1, Sco5 and Whc1) and one probable mutation affecting the regulation of the Kit gene (Sow3).
Spec (probable) Regulation (regulation) of Sow3
1) Confidence 0.62 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.24 Pain Relevance 0
Therefore, the data support that the mutants described here represent a new allelic series at the Kit locus, with three missense mutations (Sco1, Sco5 and Whc1) and one probable mutation affecting the regulation of the Kit gene (Sow3).
Spec (probable) Regulation (regulation) of Kit
2) Confidence 0.62 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.24 Pain Relevance 0
Nonetheless, a series of complementation assays with other known alleles including KitW, KitW-v and Kittm1Alf confirmed that Kit function was altered in Sow3 (Figure 1E).
Regulation (altered) of Sow3
3) Confidence 0.54 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.21 Pain Relevance 0
An impaired viability affected KitSco5 homozygotes before weaning, with only 21 mutants recovered out of 241 offspring from KitSco5/+ intercrosses.
Regulation (affected) of KitSco5
4) Confidence 0.54 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.15 Pain Relevance 0
Interestingly, the Lpic gene transcription is not significantly affected in the Sco5 mutant at these ages.
Neg (not) Regulation (affected) of Sco5
5) Confidence 0.45 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.06 Pain Relevance 0.03
RNA interference has revealed imatinib resistant GIST cells are still dependent on KIT kinase activity for activation of essential downstream signalling pathways.
Regulation (dependent) of KIT kinase associated with gastrointestinal stromal tumor
6) Confidence 0.40 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.44 Pain Relevance 0
KIT is a receptor protein kinase controlling several signaling pathways.
Regulation (controlling) of KIT
7) Confidence 0.40 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.18 Pain Relevance 0
AP controlled the Kit sequence polymorphism in several mouse lines.
Regulation (controlled) of Kit
8) Confidence 0.40 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0 Pain Relevance 0
Uterine contractions depend on KIT-positive interstitial cells in the mouse: genetic and pharmacological evidence.
Regulation (depend) of KIT in interstitial cells associated with dismenorea
9) Confidence 0.39 Published 2008 Journal Biol. Reprod. Section Title Doc Link 18480468 Disease Relevance 0.23 Pain Relevance 0.31
Nonetheless, a series of complementation assays with other known alleles including KitW, KitW-v and Kittm1Alf confirmed that Kit function was altered in Sow3 (Figure 1E).
Regulation (altered) of Kit
10) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.21 Pain Relevance 0
In this paper, we described three new point mutations inducing loss-of-function of the KIT protein (Sco1, Sco5 and Whc1) and one potential mutation affecting the regulation of the Kit gene (Sow3).
Regulation (regulation) of Kit
11) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0 Pain Relevance 0
In this paper, we described three new point mutations inducing loss-of-function of the KIT protein (Sco1, Sco5 and Whc1) and one potential mutation affecting the regulation of the Kit gene (Sow3).
Regulation (regulation) of Sow3
12) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0 Pain Relevance 0
Most of them correspond to large chromosomal rearrangement whereas Sow3 is presumably a point mutation induced by ENU affecting a regulatory element controlling Kit during melanogenesis and gametogenesis.
Regulation (controlling) of Kit
13) Confidence 0.24 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0 Pain Relevance 0
Characterization of a new allelic series of mutants affecting the Kit gene
Regulation (affecting) of Kit
14) Confidence 0.24 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.15 Pain Relevance 0
The Kit-dependent UVB response was characterized largely by an enrichment of oxidative and endoplasmic reticulum stress genes, highlighting a distinctive role for pigmented melanocytes in mediating antioxidant defenses against genotoxic stresses within the basal epidermal environment.
Regulation (response) of Kit-dependent in reticulum associated with stress and dna damage
15) Confidence 0.22 Published 2007 Journal PLoS Genetics Section Abstract Doc Link PMC1774588 Disease Relevance 0.67 Pain Relevance 0.21
Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation.
Regulation (regulation) of c-kit in stem cell associated with pain
16) Confidence 0.21 Published 2008 Journal Neuroscience Section Title Doc Link 18423881 Disease Relevance 0.25 Pain Relevance 0.84
However, there was twice the density of mast cells in their normal compared to their heterozygous littermates, suggesting a c-kit gene dosage effect on mast cell density (p < 0.05).
Regulation (effect) of c-kit in mast cells
17) Confidence 0.18 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074344 Disease Relevance 0.31 Pain Relevance 0.03
The function of BCR-ABL has allowed the design and development of imatinib, a small-molecule kinase inhibitor that targets PDGFR, c-Kit, and ABL kinases (Deininger et al 2005).
Regulation (targets) of c-Kit
18) Confidence 0.17 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 1.11 Pain Relevance 0.05
Normal small intestine was used as the internal control for kit, SMA and S-100.
Regulation (control) of kit in internal
19) Confidence 0.15 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1633731 Disease Relevance 0.90 Pain Relevance 0.03
The introduction of imatinib, a tyrosine kinase inhibitor mainly targeting BCR-ABL, c-KIT and PDGFR, has profoundly improved the prognosis of both entities, while being surprisingly well tolerated.
Regulation (targeting) of c-KIT
20) Confidence 0.13 Published 2009 Journal Drug Saf Section Abstract Doc Link 19810774 Disease Relevance 1.17 Pain Relevance 0.06

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