INT14018

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Context Info
Confidence 0.31
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.84
Pain Relevance 4.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) nucleus (Rbm39)
Anatomy Link Frequency
brain 4
respiratory 2
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 22 100.00 Very High Very High Very High
opioid receptor 18 100.00 Very High Very High Very High
antagonist 7 100.00 Very High Very High Very High
Opioid 13 99.76 Very High Very High Very High
Analgesic 10 99.40 Very High Very High Very High
depression 6 98.80 Very High Very High Very High
agonist 8 97.60 Very High Very High Very High
Enkephalin 4 96.72 Very High Very High Very High
antinociception 7 95.40 Very High Very High Very High
analgesia 8 93.44 High High
Disease Link Frequency Relevance Heat
Coma 4 99.80 Very High Very High Very High
Targeted Disruption 5 99.00 Very High Very High Very High
Respiratory Failure 5 98.80 Very High Very High Very High
Nociception 42 94.24 High High
Ganglion Cysts 2 82.40 Quite High
Pain 5 79.52 Quite High
Stress 3 76.16 Quite High
Brain Concussion 1 69.60 Quite High
Hypoalagesia 1 61.20 Quite High
Neuroblastoma 1 27.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant reduction in [3H]deltorphin-I binding to delta receptors and a significant increase in [3H]CI-977 binding to kappa receptors was detected in the spinal cords but not in the brains of the knock-out mice.
Negative_regulation (reduction) of receptors Binding (binding) of in brains associated with targeted disruption
1) Confidence 0.31 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12417646 Disease Relevance 0.55 Pain Relevance 0.81
We conclude that the predictability of the degree of respiratory depression produced by a given analgesic dose of an opioid appears to decrease with its selectivity for mu opioid receptors, at least in the mouse.
Spec (appears) Negative_regulation (decrease) of receptors Binding (selectivity) of in respiratory associated with depression, analgesic, respiratory failure, mu opioid receptor and opioid
2) Confidence 0.16 Published 1991 Journal Br J Anaesth Section Abstract Doc Link 1684279 Disease Relevance 0.41 Pain Relevance 1.29
In rodent brain membranes, the 5-benzyl derivative showed high affinity at the micro opioid receptor and decreased interaction with delta and kappa receptors, hence displaying a similar binding profile as 14-MM.
Negative_regulation (decreased) of receptors Binding (interaction) of in brain associated with opioid receptor
3) Confidence 0.05 Published 2010 Journal Eur J Pharm Sci Section Abstract Doc Link 20600882 Disease Relevance 0.25 Pain Relevance 1.10
The effect of DADLE (1 microM) was blocked by the mu-antagonist D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP; 300 nM) but not by the -antagonist Tyr-1,2,3,4-tetrahydroisoquinoline-Phe-Phe-OH (300 nM), implicating mu receptors.
Negative_regulation (blocked) of receptors Binding (implicating) of associated with antagonist
4) Confidence 0.03 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16135785 Disease Relevance 0.16 Pain Relevance 0.53
Among the series of derivatives, 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-3, 4-dihydro-5-methoxy-2(1H)-quinolinone hydrochloride (34b) and its mesylate (34c), at a dose of 30 mg/kg po, reduced the sleeping time and the time for recovery from coma and they inhibited [(3)H]DTG binding for sigma receptors.
Negative_regulation (inhibited) of receptors Binding (binding) of associated with coma
5) Confidence 0.02 Published 2000 Journal J. Med. Chem. Section Abstract Doc Link 10649973 Disease Relevance 0.38 Pain Relevance 0.41
A methoxy substituent in the C8' position decreases the binding affinity for both the mu and delta receptors, while a C10' methoxy substituent has little effect on either binding affinity.
Negative_regulation (decreases) of receptors Binding (affinity) of
6) Confidence 0.01 Published 1996 Journal J. Med. Chem. Section Abstract Doc Link 8642567 Disease Relevance 0 Pain Relevance 0.15
The increased affinity of opioid receptors has been previously shown to result from a decrease of phosphorylation, oligomerization and allosterism of opioid receptors [45].
Negative_regulation (decrease) of receptors Binding (oligomerization) of associated with opioid receptor
7) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.08 Pain Relevance 0.64

General Comments

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