INT140186

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Context Info
Confidence 0.55
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.04
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
joints 4
extracellular matrix 4
articular 2
cartilage 2
Mmp3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 267 100.00 Very High Very High Very High
Osteoarthritis 25 99.84 Very High Very High Very High
rheumatoid arthritis 259 99.66 Very High Very High Very High
Arthritis 162 96.64 Very High Very High Very High
Inflammation 123 96.08 Very High Very High Very High
cytokine 88 83.96 Quite High
antagonist 4 76.44 Quite High
Snapping jaw 1 75.00 Quite High
Leflunomide 2 68.64 Quite High
COX-2 inhibitor 5 67.80 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 25 99.84 Very High Very High Very High
Hypoxia 6 99.84 Very High Very High Very High
Rheumatoid Arthritis 259 99.66 Very High Very High Very High
Coronary Aneurysm 16 98.24 Very High Very High Very High
Arthritis 168 96.64 Very High Very High Very High
INFLAMMATION 111 96.08 Very High Very High Very High
Aneurism 21 94.56 High High
Adhesions 10 90.08 High High
Hyperplasia 4 88.00 High High
Disease 92 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is in line with previous reports that demonstrated elevated MMP-3 expression levels in synovial fluids and sera of patients with rheumatoid arthritis as well as expression in joints of CIA rats [10-12].
Positive_regulation (elevated) of Gene_expression (expression) of MMP-3 in joints associated with rheumatoid arthritis, metalloproteinase and arthritis
1) Confidence 0.55 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 1.26 Pain Relevance 0.74
The objective of our study was to determine whether the expression of Mmp-3, Mmp-13 and Ddr2 was increased in OA-like TM joints in mutant mice using immunohistochemistry.
Spec (whether) Positive_regulation (increased) of Gene_expression (expression) of Mmp-3 in joints associated with osteoarthritis
2) Confidence 0.49 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.35 Pain Relevance 0.32
We conclude that MMP-3 overexpression due to a proteolytic imbalance may lead to coronary aneurysm development through degradation of matrix components, especially lamina elastica.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MMP-3 in lamina associated with coronary aneurysm
3) Confidence 0.41 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.65 Pain Relevance 0.30
An increased propensity for extracellular matrix (ECM) remodeling is suggested by elevated expression of matrix metalloproteinases (Mmp3, Mmp9 and Mmp13), urokinase-type plasminogen activator (Plau) and secreted protease inhibitors (Serpina3g, Serpin2 and Lcn2).
Positive_regulation (elevated) of Gene_expression (expression) of Mmp3 in extracellular matrix associated with metalloproteinase
4) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.43 Pain Relevance 0.09
driven matrix metalloproteinases (MMP) synthesis resulting in the down-regulation of MMP-1 and MMP-3 production in vitro.
Positive_regulation (resulting) of Gene_expression (production) of MMP-3 associated with metalloproteinase
5) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888198 Disease Relevance 0.96 Pain Relevance 0.86
Consistent with our finding in RA FLS monocultures, we found that BACE/RA FLS co-cultures produced negligible MMP-3 in response to IFN-?
Positive_regulation (response) of Gene_expression (produced) of MMP-3 associated with metalloproteinase and rheumatoid arthritis
6) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.99 Pain Relevance 0.66
One of the triggering factors appears to be articular hypoxia, which stimulates both synthesis of proangiogenic factors but also the expression of chemotactic factors, MMPs such as MMP-1 and MMP-3 (combined with a downregulation of TIMP-1 in RASFs), and osteoclastogenic factors such as inhibitor of differentiation [54].
Positive_regulation (stimulates) of Gene_expression (expression) of MMP-3 in articular associated with hypoxia and metalloproteinase
7) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.53 Pain Relevance 0.34
The expression of MMP-3 is particularly high in synovial tissue from RA patients, suggesting that MMP-3 plays a significant role in the progression of erosions of the cartilage [52].
Positive_regulation (high) of Gene_expression (expression) of MMP-3 in cartilage associated with rheumatoid arthritis
8) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.88 Pain Relevance 0.51

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