INT140188

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.54
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Ddr2) plasma membrane (Ddr2) kinase activity (Ddr2)
Anatomy Link Frequency
joints 6
TMJ 4
Ddr2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 8 100.00 Very High Very High Very High
Osteoarthritis 18 99.84 Very High Very High Very High
Snapping jaw 8 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 18 99.84 Very High Very High Very High
Temporomandibular Joint Syndrome 8 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Results indicate that partial discectomy induces early-onset OA in mouse TMJ and that increased expression of Mmp-13, likely due to the elevated expression of Ddr2, may be one of the factors responsible for the early-onset OA in mouse TMJ.


Positive_regulation (elevated) of Gene_expression (expression) of Ddr2 in TMJ
1) Confidence 0.69 Published 2009 Journal Osteoarthr. Cartil. Section Body Doc Link 19230720 Disease Relevance 0.11 Pain Relevance 0
We found that the staining for Ddr2, Mmp-13 and Mmp-derived type II collagen fragments in tissue sections from 6-month-old mice was increased in TM joints of the mutant mice.
Positive_regulation (increased) of Gene_expression (staining) of Ddr2 in joints
2) Confidence 0.50 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.33 Pain Relevance 0.32
The objective of our study was to determine whether the expression of Mmp-3, Mmp-13 and Ddr2 was increased in OA-like TM joints in mutant mice using immunohistochemistry.
Spec (whether) Positive_regulation (increased) of Spec (whether) Gene_expression (expression) of Ddr2 in joints associated with osteoarthritis
3) Confidence 0.50 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.35 Pain Relevance 0.32
We conclude that, similar to previous observations in knee joints, the overexpression of Ddr2 and Mmp-13 may be responsible for the OA-like change in TM joints in mutant mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Ddr2 in joints associated with osteoarthritis
4) Confidence 0.50 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.39 Pain Relevance 0.30
Age-dependent increase of discoidin domain receptor 2 and matrix metalloproteinase 13 expression in temporomandibular joint cartilage of type IX and type XI collagen-deficient mice.
Positive_regulation (increase) of Gene_expression (expression) of domain receptor 2 in temporomandibular joint associated with snapping jaw and metalloproteinase
5) Confidence 0.44 Published 2007 Journal Arch. Oral Biol. Section Title Doc Link 17125729 Disease Relevance 0.36 Pain Relevance 0.35

General Comments

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